J
Jean-Christophe Andrau
Researcher at University of Montpellier
Publications - 46
Citations - 3485
Jean-Christophe Andrau is an academic researcher from University of Montpellier. The author has contributed to research in topics: Enhancer & RNA polymerase II. The author has an hindex of 24, co-authored 42 publications receiving 2887 citations. Previous affiliations of Jean-Christophe Andrau include Centre national de la recherche scientifique & Aix-Marseille University.
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Journal ArticleDOI
Noncoding Transcription at Enhancers: General Principles and Functional Models
TL;DR: The possibility that enhancer transcription and the resulting enhancer RNAs may, in some cases, have functional roles, rather than represent mere transcriptional noise at accessible genomic regions, is supported by an increasing amount of experimental data.
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H3K4 tri-methylation provides an epigenetic signature of active enhancers.
Aleksandra Pekowska,Touati Benoukraf,Joaquin Zacarias-Cabeza,Mohamed Belhocine,Frederic Koch,Hélène Holota,Jean Imbert,Jean-Christophe Andrau,Pierre Ferrier,Salvatore Spicuglia +9 more
TL;DR: The results suggest the existence of functional links between Pol II occupancy, H3K4me3 enrichment and enhancer activity, and suggest the activity of bona fide T‐cell gene enhancers is regulated by Pol II.
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Transcription initiation platforms and GTF recruitment at tissue-specific enhancers and promoters
Frederic Koch,Romain Fenouil,Marta Gut,Pierre Cauchy,Thomas K Albert,Joaquin Zacarias-Cabeza,Salvatore Spicuglia,Albane Lamy de la Chapelle,Martin Heidemann,Corinna Hintermair,Dirk Eick,Ivo Gut,Pierre Ferrier,Jean-Christophe Andrau +13 more
TL;DR: It is proposed that TIPs represent important new regulatory hallmarks of the genome by identifying genomic features called transcriptional initiation platforms (TIPs) characterized by large areas of Pol II and GTF recruitment at promoters, intergenic and intragenic regions.
Journal ArticleDOI
Argonaute proteins couple chromatin silencing to alternative splicing.
Maya Ameyar-Zazoua,Christophe Rachez,Mouloud Souidi,Philippe Robin,Lauriane Fritsch,Robert Young,Nadya Morozova,Romain Fenouil,Nicolas Descostes,Jean-Christophe Andrau,Jacques Mathieu,Ali Hamiche,Slimane Ait-Si-Ali,Christian Muchardt,Eric Batsché,Annick Harel-Bellan +15 more
TL;DR: It is shown that AGO1 and AGO2 facilitate spliceosome recruitment and modulate RNA polymerase II elongation rate, thereby affecting alternative splicing, and uncovered a new model for the regulation of alternativesplicing, in which Argonaute proteins couple RNA polymerases II elongations to chromatin modification.
Journal ArticleDOI
CpG islands and GC content dictate nucleosome depletion in a transcription-independent manner at mammalian promoters
Romain Fenouil,Pierre Cauchy,Frederic Koch,Frederic Koch,Frederic Koch,Nicolas Descostes,Nicolas Descostes,Nicolas Descostes,Joaquin Zacarias Cabeza,Joaquin Zacarias Cabeza,Joaquin Zacarias Cabeza,Charlène Innocenti,Charlène Innocenti,Charlène Innocenti,Pierre Ferrier,Pierre Ferrier,Pierre Ferrier,Salvatore Spicuglia,Salvatore Spicuglia,Salvatore Spicuglia,Marta Gut,Ivo Gut,Jean-Christophe Andrau,Jean-Christophe Andrau,Jean-Christophe Andrau +24 more
TL;DR: The data support the idea that CGIs have become an essential feature of promoter structure defining novel regulatory properties in mammals, and show that CpG content and CGI width correlate with nucleosome depletion both in vivo and in vitro.