J
Jean-Christophe Audonnet
Researcher at Rensselaer Polytechnic Institute
Publications - 34
Citations - 1347
Jean-Christophe Audonnet is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Virus & Recombinant virus. The author has an hindex of 11, co-authored 34 publications receiving 1330 citations.
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Journal ArticleDOI
NYVAC: a highly attenuated strain of vaccinia virus
James Tartaglia,Marion E. Perkus,Jill Taylor,Elizabeth K. Norton,Jean-Christophe Audonnet,William I. Cox,Stephen W. Davis,Johanna Van Der Hoeven,Bernard Meignier,Michel Riviere,Bernard Languet,Enzo Paoletti +11 more
TL;DR: The NYVAC strain was demonstrated to be highly attenuated by the following criteria: greatly reduced virulence as demonstrated by the results of intracranial challenge of both 3-week-old or newborn mice; greatly reduced pathogenicity and failure to disseminate in immunodeficient (nude or cyclophosphamide treated) mice.
Patent
NYVAC vaccinia virus recombinants comprising heterologous inserts
Enzo Paoletti,Marion E. Perkus,Jill Taylor,James Tartaglia,Elizabeth K. Norton,Michel Riviere,Charles de Taisne,Keith J. Limbach,Gerard P. Johnson,Steven E. Pincus,William I. Cox,Jean-Christophe Audonnet,Russell Robert Gettig +12 more
TL;DR: In this article, a modified recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety is described, where the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor.
Journal ArticleDOI
Herpesvirus of turkey recombinant viruses expressing infectious bursal disease virus (IBDV) VP2 immunogen induce protection against an IBDV virulent challenge in chickens.
Raphael Jean Darteil,Michel Bublot,Eliane Louise Françoise Laplace,Jean-Francois Bouquet,Jean-Christophe Audonnet,Michel Riviere +5 more
TL;DR: In spite of the low protection level against MDV, this is the first report which describes induction of full protection against IBDV with a single inoculation of a recombinant virus.
Journal ArticleDOI
The Complete DNA Sequence and the Genetic Organization of the Short Unique Region (US) of the Bovine Herpesvirus Type 1 (ST Strain)
TL;DR: The genetic content and the genomic organization of its US region was found to be similar to the general organization already described for HSV- 1, EHV-1, PRV, and avian herpesviruses HVT and MDV US regions.
Journal ArticleDOI
Equine herpesvirus type 1 unique short fragment encodes glycoproteins with homology to herpes simplex virus type 1 gD, gI and gE.
TL;DR: It is concluded that EHV- 1, PRV, HSV-1 and VZV encode homologous glycoprotein genes in the small unique components of their genomes and that the genetic organization of these regions is conserved.