S
Stephen W. Davis
Researcher at Rensselaer Polytechnic Institute
Publications - 8
Citations - 2079
Stephen W. Davis is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Vaccinia & Orthopoxvirus. The author has an hindex of 8, co-authored 8 publications receiving 2034 citations.
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Journal ArticleDOI
The complete DNA sequence of vaccinia virus
Scott J. Goebel,Gerard P. Johnson,Marion E. Perkus,Stephen W. Davis,Joseph P. Winslow,Enzo Paoletti +5 more
TL;DR: The complete DNA sequence of the genome of vaccinia virus has been determined and several similarities to proteins of known function were discerned, but the function of the majority of proteins encoded by these open reading frames is as yet undetermined.
Journal ArticleDOI
NYVAC: a highly attenuated strain of vaccinia virus
James Tartaglia,Marion E. Perkus,Jill Taylor,Elizabeth K. Norton,Jean-Christophe Audonnet,William I. Cox,Stephen W. Davis,Johanna Van Der Hoeven,Bernard Meignier,Michel Riviere,Bernard Languet,Enzo Paoletti +11 more
TL;DR: The NYVAC strain was demonstrated to be highly attenuated by the following criteria: greatly reduced virulence as demonstrated by the results of intracranial challenge of both 3-week-old or newborn mice; greatly reduced pathogenicity and failure to disseminate in immunodeficient (nude or cyclophosphamide treated) mice.
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Construction of live vaccines by using genetically engineered poxviruses: biological activity of recombinant vaccinia virus expressing influenza virus hemagglutinin.
TL;DR: The production of antibodies directed against influenza HA suggested that the HA gene expressed in vaccinia is immunogenic, indicating the potential of genetically engineered poxviruses for use as generic live vaccine vehicles that have both human and veterinary applications.
Journal ArticleDOI
Vaccinia virus host range genes.
Marion E. Perkus,Scott J. Goebel,Stephen W. Davis,Gerard P. Johnson,Keith J. Limbach,Elizabeth K. Norton,Enzo Paoletti +6 more
TL;DR: A gene encoding an 18-kDa polypeptide located in the vaccinia virus HindIII C fragment was shown to be functionally equivalent to previously described host range gene (ORF K1L) spanning the HindIII K/M fragment junction.
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Deletion of 55 open reading frames from the termini of vaccinia virus.
Marion E. Perkus,Scott J. Goebel,Stephen W. Davis,Gerard P. Johnson,Elizabeth K. Norton,Enzo Paoletti +5 more
TL;DR: Using plasmids containing repetitive DNA as the external arm, the engineered deletion within a single vaccinia virus of 32.7 kb of DNA from the left terminus and 14.9 kb from the right terminus is reported.