J
Johanna Van Der Hoeven
Researcher at Rensselaer Polytechnic Institute
Publications - 1
Citations - 518
Johanna Van Der Hoeven is an academic researcher from Rensselaer Polytechnic Institute. The author has contributed to research in topics: Viral replication & Virus. The author has an hindex of 1, co-authored 1 publications receiving 509 citations.
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NYVAC: a highly attenuated strain of vaccinia virus
James Tartaglia,Marion E. Perkus,Jill Taylor,Elizabeth K. Norton,Jean-Christophe Audonnet,William I. Cox,Stephen W. Davis,Johanna Van Der Hoeven,Bernard Meignier,Michel Riviere,Bernard Languet,Enzo Paoletti +11 more
TL;DR: The NYVAC strain was demonstrated to be highly attenuated by the following criteria: greatly reduced virulence as demonstrated by the results of intracranial challenge of both 3-week-old or newborn mice; greatly reduced pathogenicity and failure to disseminate in immunodeficient (nude or cyclophosphamide treated) mice.