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Jean-Claude Alvarez

Researcher at Université Paris-Saclay

Publications -  259
Citations -  4072

Jean-Claude Alvarez is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 33, co-authored 215 publications receiving 3415 citations. Previous affiliations of Jean-Claude Alvarez include French Institute of Health and Medical Research & Versailles Saint-Quentin-en-Yvelines University.

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Diagnosis of adrenal insufficiency in severe sepsis and septic shock.

TL;DR: In sepsis, adrenal insufficiency is likely when baseline cortisol levels are less than 10 microg/dl or delta cortisol is less than 9 microg /dl, and unlikely when cosyntropin-stimulated cortisol level is 44 microg//dl or greater or Delta cortisol is 16.8microg/DL or greater.
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A high-performance liquid chromatography method with photodiode-array UV detection for therapeutic drug monitoring of the nontricyclic antidepressant drugs.

TL;DR: The performance of the method allows the therapeutic drug monitoring of the most prescribed nontricyclic antidepressant drugs as well as its use in toxicologic screening.
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Lack of impact of intravenous lidocaine on analgesia, functional recovery, and nociceptive pain threshold after total hip arthroplasty.

TL;DR: Low dose perioperative intravenous lidocaine after total hip arthroplasty offers no beneficial effect on postoperative analgesia and does not modify pressure and tactile pain thresholds.
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Simultaneous determination of thirteen β-blockers and one metabolite by gradient high-performance liquid chromatography with photodiode-array UV detection

TL;DR: The performance of the HPLC method allows its use in toxicological screening and in quantification of the most prescribed beta-blockers drugs.
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Droperidol and ondansetron-induced QT interval prolongation: a clinical drug interaction study.

TL;DR: Under controlled conditions, both droperidol and ondansetron either alone or in combination induced significant marked QTc interval prolongation, however, the combination of both drugs did not significantly increaseQTc prolongation compared with that induced by dro peridol alone.