J
Jean-Claude Boucaut
Researcher at Pierre-and-Marie-Curie University
Publications - 65
Citations - 3294
Jean-Claude Boucaut is an academic researcher from Pierre-and-Marie-Curie University. The author has contributed to research in topics: Gastrulation & Mesoderm. The author has an hindex of 30, co-authored 64 publications receiving 3236 citations. Previous affiliations of Jean-Claude Boucaut include Centre national de la recherche scientifique & University of Paris.
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Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryos.
TL;DR: The results demonstrate the feasibility of using synthetic peptides directed at recognition sites in extracellular proteins as probes of morphogenetic processes, and provide further support for the hypothesis that fibronectin is involved in gastrulation and neural crest cell migration.
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Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis
TL;DR: In this article, the authors describe the expression and functional analyses of frizzled 7 (Xfz7) during gastrulation in Xenopus and suggest an endogenous role of Xfz-7 in the regulation of convergent extension during Gastrulation.
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The C-terminal cytoplasmic Lys-Thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/β-catenin signalling
Muriel Umbhauer,Alexandre Djiane,Céline Goisset,Alfredo Penzo-Méndez,Jean-François Riou,Jean-Claude Boucaut,De-Li Shi +6 more
TL;DR: Functional evidence supporting a role of this conserved motif in the modulation of Wnt signalling is provided, consistent with the genetic features exhibited by Drosophila Dfz3 and Caenorhabditis elegans mom‐5 in which the tryptophan is substituted by a tyrosine.
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A truncated FGF receptor blocks neural induction by endogenous Xenopus inducers.
TL;DR: It is shown that the specification of the most anterior neuroectoderm by noggin may occur before gastrulation and does not require FGF signalling, since both the cement gland marker XCG-1 and the anterior neural marker Otx-2 are normally expressed in ectodermal explants co-injected with noggins and XFD RNAs, but the cement glands cells are poorly differentiated.
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Frizzled receptor dimerization is sufficient to activate the Wnt/β-catenin pathway
TL;DR: Using early Xenopus embryos, it is shown that frizzled receptors can dimerize and that dimerization is correlated with activation of the Wnt/β-catenin pathway, and it is suggested thatDimerization contributes to transducing the WNT/ β-Catenin signal.