M
Muriel Umbhauer
Researcher at University of Paris
Publications - 34
Citations - 1910
Muriel Umbhauer is an academic researcher from University of Paris. The author has contributed to research in topics: Xenopus & Mesoderm. The author has an hindex of 18, co-authored 30 publications receiving 1779 citations. Previous affiliations of Muriel Umbhauer include Pierre-and-Marie-Curie University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis
TL;DR: In this article, the authors describe the expression and functional analyses of frizzled 7 (Xfz7) during gastrulation in Xenopus and suggest an endogenous role of Xfz-7 in the regulation of convergent extension during Gastrulation.
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The C-terminal cytoplasmic Lys-Thr-X-X-X-Trp motif in frizzled receptors mediates Wnt/β-catenin signalling
Muriel Umbhauer,Alexandre Djiane,Céline Goisset,Alfredo Penzo-Méndez,Jean-François Riou,Jean-Claude Boucaut,De-Li Shi +6 more
TL;DR: Functional evidence supporting a role of this conserved motif in the modulation of Wnt signalling is provided, consistent with the genetic features exhibited by Drosophila Dfz3 and Caenorhabditis elegans mom‐5 in which the tryptophan is substituted by a tyrosine.
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The Xenopus Brachyury promoter is activated by FGF and low concentrations ofactivinandsuppressed by high concentrationsof activin and by paired-type homeodomain proteins
Brancko V. Latinkic,Muriel Umbhauer,Kathy A. Neal,Walter Lerchner,James C. Smith,Vincent T. Cunliffe +5 more
TL;DR: It is shown that 381 bp 5' of the Xbra2 transcription start site are sufficient to confer responsiveness both to FGF and, in a concentration-dependent manner, to activin, which offers an excellent paradigm for studying the way in which a morphogen gradient is interpreted in vertebrate embryos.
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Frizzled receptor dimerization is sufficient to activate the Wnt/β-catenin pathway
TL;DR: Using early Xenopus embryos, it is shown that frizzled receptors can dimerize and that dimerization is correlated with activation of the Wnt/β-catenin pathway, and it is suggested thatDimerization contributes to transducing the WNT/ β-Catenin signal.
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Neofunctionalization in vertebrates: The example of retinoic acid receptors
Hector Escriva,Stéphanie Bertrand,Pierre Germain,Marc Robinson-Rechavi,Muriel Umbhauer,Jérôme Cartry,Marilyne Duffraisse,Linda Z. Holland,Hinrich Gronemeyer,Vincent Laudet +9 more
TL;DR: It is suggested that neofunctionalization occurred at both the expression and the functional levels to shape RAR roles during development in vertebrates, including a reconstructed synthetic RAR representing the receptor present in the ancestor of chordates.