J
Jean Claude Ourlin
Researcher at French Institute of Health and Medical Research
Publications - 3
Citations - 191
Jean Claude Ourlin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Gene & Pregnane X receptor. The author has an hindex of 3, co-authored 3 publications receiving 188 citations.
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Journal ArticleDOI
The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.
Jean Claude Ourlin,Frédéric Lasserre,Thierry Pineau,Jean Michel Fabre,Antonio Sa-Cunha,Patrick Maurel,Marie-José Vilarem,Jean-Marc Pascussi +7 more
TL;DR: An elaborate regulatory cascade, tightly controlled by SHP, is revealed for both the maintenance of bile acid production and detoxification in the liver, as well as in vivo in mice.
Journal ArticleDOI
Role of the liver-enriched transcription factors C/EBPα and DBP in the expression of human CYP3A4 and CYP3A7
TL;DR: Results suggest that C/EBP alpha, and possibly other members of the C/eBP family, play a prominent part in the expression of the CYP3A family in man, and that the two genes respond differently to C/ EBP alpha and DBP, two factors that exhibit a strict proliferation-dependent pattern of expression in the liver.
Journal ArticleDOI
Lipid-Mediated Transfection of Normal Adult Human Hepatocytes in Primary Culture☆
Jean Claude Ourlin,Marie-José Vilarem,Martine Daujat,Marie-Cécile Harricane,Jacques Domergue,Joyeux H,Jean Baulieux,Patrick Maurel +7 more
TL;DR: It is concluded that normal adult human hepatocytes can be transfecting with exogenous DNA and that the transfected construct is regulated in the manner expected from in vivo studies.