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Jean-Daniel Brion

Researcher at Centre national de la recherche scientifique

Publications -  257
Citations -  5108

Jean-Daniel Brion is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Catalysis & Aryl. The author has an hindex of 41, co-authored 256 publications receiving 4734 citations. Previous affiliations of Jean-Daniel Brion include Institut de Chimie des Substances Naturelles & Université Paris-Saclay.

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Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.

Samir Messaoudi, +12 more
- 16 Jun 2009 - 
TL;DR: These compounds having a 1,1-diarylethylene scaffold constitute the simplest isomers of natural Z-combretastatins A that are easy to synthesize without need to control the Z-olefin geometry.
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Transition-Metal-Catalyzed Direct C–H Alkenylation, Alkynylation, Benzylation, and Alkylation of (Hetero)arenes

Samir Messaoudi, +2 more
- 01 Dec 2010 - 
TL;DR: This micro-review summarizes the development in this area to date, with the focus on how the substrate scope has been expanded through selection of more appropriate synthetic methods, such as the careful choice of catalysts, ligands, bases and reaction conditions.
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Palladium(II)-Catalyzed Oxidative Arylation of Quinoxalin-2(1H)-ones with Arylboronic Acids

Amandine Carrer, +3 more
- 11 Oct 2013 - 
TL;DR: A straightforward palladium-catalyzed oxidative C-3 arylation of quinoxalin-2(1H)-ones with arylboronic acids is reported, compatible with a wide range of functional groups and allows construction of various biologically important quinxalin-1H-one backbones.
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New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

Gaëlle Le Bras, +7 more
- 03 Nov 2007 - 
TL;DR: This structure-activity relationship study highlights the crucial role of the C-4 and/or C-7 positions of coumarin which appeared to be essential for degradation of hsp90 client proteins.
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Discovery of Isoerianin Analogues as Promising Anticancer Agents

Samir Messaoudi, +11 more
- 07 Mar 2011 - 
TL;DR: It clearly appears that in this compound series, the 1,1‐ethane bridge encountered in isoerianin derivatives can replace the 1‐ethylene bridge of natural erianin with no loss of activity, which reinforces the bioisosteric replacement approach in the combretastatin series previously reported by the research group.