J
Jean-Louis Mege
Researcher at French Institute of Health and Medical Research
Publications - 12
Citations - 650
Jean-Louis Mege is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Rickettsia prowazekii & Cell adhesion. The author has an hindex of 4, co-authored 12 publications receiving 453 citations. Previous affiliations of Jean-Louis Mege include University of the Mediterranean.
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Journal ArticleDOI
From Q Fever to Coxiella burnetii Infection: a Paradigm Change.
Carole Eldin,Cléa Melenotte,Oleg Mediannikov,Eric Ghigo,Matthieu Million,Sophie Edouard,Jean-Louis Mege,Max Maurin,Didier Raoult +8 more
TL;DR: All the progress made over the last 20 years on this topic are reviewed, including the breaking of the old dichotomy between “acute” and “chronic” Q fever and the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses.
Journal ArticleDOI
Adipose Tissue Serves as a Reservoir for Recrudescent Rickettsia prowazekii Infection in a Mouse Model
TL;DR: A murine model for Brill-Zinsser disease is described, and PCR and cell culture are used to show transient rickettsemia in mice treated with dexamethasone, suggesting a role for adipose tissue as a potential reservoir for dormant infections with R. prowazekii.
Book ChapterDOI
Sex Hormones and Bacterial Infections
TL;DR: The present review focuses on four features of the association between sex and bacterial infections with a special attention for bacterial sepsis, mycobacterial infections and Coxiella burnetii infection.
Journal ArticleDOI
Cytomegalovirus reactivation enhances the virulence of Staphylococcus aureus pneumonia in a mouse model
Sami Hraiech,Sami Hraiech,J Bordes,Jean-Louis Mege,X. de Lamballerie,Rémi N. Charrel,Y Bechah,Boris Pastorino,Christophe Guervilly,Jean-Marie Forel,M. Adda,Jean-Marc Rolain,Hubert Lepidi,Didier Raoult,Samuel Lehingue,Laurent Papazian,Laurent Papazian +16 more
TL;DR: MCMV reactivation decreased lung bacterial clearance and favoured the development of staphylococcal abscessing pneumonia and may be responsible for a higher susceptibility to bacterial sepsis.
Book ChapterDOI
New Tools for Studying Macrophage Polarization: Application to Bacterial Infections
Soraya Mezouar,Jean-Louis Mege +1 more
TL;DR: This review proposes to take stock of the tools for studying the polarization of macrophages and makes recommendations for using macrophage polarization as a biomarker for measuring severity and response to treatment in bacterial infectious diseases.