J
Jean-Louis Peglion
Researcher at Centre national de la recherche scientifique
Publications - 102
Citations - 865
Jean-Louis Peglion is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Alkyl & Alkoxy group. The author has an hindex of 13, co-authored 102 publications receiving 834 citations. Previous affiliations of Jean-Louis Peglion include University of Lyon.
Papers
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Journal ArticleDOI
Synthesis of Benzocyclobutenes by Palladium-Catalyzed C−H Activation of Methyl Groups: Method and Mechanistic Study
Manon Chaumontet,Riccardo Piccardi,Nicolas Audic,Julien Hitce,Jean-Louis Peglion,Eric Clot,Olivier Baudoin +6 more
TL;DR: DFT(B3PW91) calculations on the reaction of 2-bromo-tert-butylbenzene with Pd(P ( t )Bu 3) with different bases showed the critical influence of the coordination mode of the base to induce both an easy C-H activation and to allow for a pathway for 1,4-palladium migration.
Patent
Benzocyclobutyl- or indanyl-alkyl-amino-alkyl substituted 3-benzazepin-2-ones useful in the treatment of cardiovascular diseases
Jean-Louis Peglion,Joel Vian,Jean-Paul Vilaine,Nicole Villeneuve,Philip Janiak,Jean-Pierre Bidouard +5 more
TL;DR: In this paper, the authors describe compounds of formula (I) in which p and q, which are identical or different, represent 0, 1 or 2 provided that the sum p + q is equal to 1 or two.
Journal ArticleDOI
Tetracyclic analogues of [+]-S 14297: Synthesis and determination of affinity and selectivity at cloned human dopamine D3 vs D2 receptors
TL;DR: In this paper, a series of cis and trans tetracyclic derivatives of general formula I was used to improve the potency and selectivity of D3 receptors, and the trans oxazino derivative 2c showed slightly increased affinity at D3 receptor and double the selectivity for D3 over D2 receptors.
Journal ArticleDOI
Synthetic efforts toward the synthesis of octalactins
TL;DR: Octalactin B was synthesized from commercially available methyl-3-butenoate and isobutyraldehyde, using enantioselective allyl- and crotyltitanations to control the stereogenic centers at C3, C4, C7, C8, and C13.
Journal ArticleDOI
Characterization of potent and selective antagonists at postsynaptic 5-HT1A receptors in a series of N4-substituted arylpiperazines.
Jean-Louis Peglion,H Canton,K Bervoets,Valérie Audinot,Mauricette Brocco,Alain Gobert,S Le Marouille-Girardon,Millan Mark +7 more
TL;DR: Compound 14 displayed an optimal compromise between potency, marked antagonist activity, and selectivity toward alpha 1-adrenergic and dopamine D2 receptors, which clearly distinguish 14 from previously-reported ligands such as the postsynaptic 5-HT1A antagonist BMY 7378 and the weak partial agonist NAN 190.