Jean-Luc Dreyer

TL;DR: The data suggest that miR-124, let-7d and mi-181a may be involved in a complex feedback loop with cocaine-responsive plasticity genes, highlighting the possibility that some miRNAs are key regulators of the reward circuit and may be implicated in addiction.

TL;DR: Observations indicate that nuclear translocation of GAPDH may play a role in apoptosis and oxidative stress, probably related to the activity ofGAPDH as a DNA repair enzyme or as a nuclear carrier for pro-apoptotic molecules.

TL;DR: In vivo miRNA gain and loss of function on cocaine-induced conditioned place preference (CPP) by localized LV-miRNA regulation in the nucleus accumbens (NAc) is tested, describing a complex regulatory pathway mediated by miRNAs in cocaine-mediated neuronal adaptations.

TL;DR: A functional relationship between acquisition of associative learning, increase in synaptic strength at the CA3–CA1 synapse, and Egr1 induction in the hippocampus is revealed by demonstrating that all three are dramatically impaired when D1R is eliminated or reduced.

TL;DR: It is suggested that the ligand–receptor pair may contribute to the establishment of distinct neural pathways by selectively inhibiting the neurite outgrowth and cell survival of mistargeted neurons.