Jean M. Abel

TL;DR: Clinical and preclinical evidence for the efficacy of exercise at different phases of the addiction process and potential neurobiological mechanisms are discussed focusing on interactions with dopaminergic and glutamatergic signaling and chromatin remodeling in the reward pathway.

TL;DR: This is the first study demonstrating that sex chromosome genes are a driving force producing sex differences in the CB and FC, which are neuoranatomical regions involved in many normal functions and in neurobehavioral diseases.

TL;DR: Examination of the dose-dependent effects of wheel running during abstinence on subsequent cocaine-seeking and associated changes in prefrontal cortex (PFC) brain-derived neurotrophic factor (Bdnf) exon IV expression indicates that the efficacy of exercise is dose dependent and likely mediated through epigenetic regulation of PFC Bdnf.

TL;DR: It is indicated that the timing of exercise availability differentially impacts cocaine seeking with results suggesting that exercise during early, but not late, abstinence may provide long-term protection against cocaine relapse.

TL;DR: Analysis of the effects of resistance exercise on heroin self-administration and mRNA expression of genes known to mediate opioid reinforcement and addictive behavior in the nucleus accumbens of heroin-exposed rats indicates that resistance exercise decreases the positive reinforcing effects of heroin and produces changes in opioid and dopamine systems in the NAc of heroin