Exercise as a novel treatment for drug addiction: a neurobiological and stage-dependent hypothesis.
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TLDR
Clinical and preclinical evidence for the efficacy of exercise at different phases of the addiction process and potential neurobiological mechanisms are discussed focusing on interactions with dopaminergic and glutamatergic signaling and chromatin remodeling in the reward pathway.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2013-09-01 and is currently open access. It has received 239 citations till now. The article focuses on the topics: Addiction & Population.read more
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Dopamine: Functions, Signaling, and Association with Neurological Diseases
Marianne O. Klein,Daniella S. Battagello,Ariel R. Cardoso,David N. Hauser,Jackson C. Bittencourt,Ricardo G. Correa +5 more
TL;DR: The aspects of dopamine as a catecholaminergic neurotransmitter and dopamine signaling pathways elicited through dopamine receptor activation in normal brain function are summarized and the potential involvement of these signaling pathways in evoking the onset and progression of some diseases in the nervous system are described.
Journal ArticleDOI
Health Benefits of Exercise
TL;DR: It is now clear that physical training is complex biology, invoking polygenic interactions within cells, tissues/organs, systems, with remarkable cross talk occurring among the former list.
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Impact of Physical Exercise on Substance Use Disorders: A Meta-Analysis
TL;DR: The moderate and high-intensity aerobic exercises, designed according to the Guidelines of American College of Sports Medicine, and the mind-body exercises can be an effective and persistent treatment for those with SUD.
Journal ArticleDOI
Exercise-based treatments for substance use disorders: evidence, theory, and practicality
Sarah E. Linke,Michael Ussher +1 more
TL;DR: The limited research conducted suggests that exercise may be an effective adjunctive treatment for SUDs, including psychological, behavioral, neurobiological, nearly universal safety profile, and overall positive health effects.
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Exercise and alcohol consumption: what we know, what we need to know, and why it is important
TL;DR: A better understanding of the relationship between physical activity and alcohol intake will maximize intervention efforts by informing the design of clinical trials and research-driven prevention strategies, as well as enable individuals to make educated decisions about their health behaviors.
References
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Journal ArticleDOI
Actual causes of death in the United States, 2000.
TL;DR: These analyses show that smoking remains the leading cause of mortality in the United States, however, poor diet and physical inactivity may soon overtake tobacco as the lead cause of death.
Journal ArticleDOI
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
G. Di Chiara,Assunta Imperato +1 more
TL;DR: The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus accumbens septi (a limbic area) and the dorsal caudate nucleus (a subcortical motor area), was studied in freely moving rats by using brain dialysis as mentioned in this paper.
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Neurocircuitry of Addiction
George F. Koob,Nora D. Volkow +1 more
TL;DR: The delineation of the neurocircuitry of the evolving stages of the addiction syndrome forms a heuristic basis for the search for the molecular, genetic, and neuropharmacological neuroadaptations that are key to vulnerability for developing and maintaining addiction.
Journal ArticleDOI
The Neural Basis of Addiction: A Pathology of Motivation and Choice
Peter W. Kalivas,Nora D. Volkow +1 more
TL;DR: Cellular adaptations in prefrontal glutamatergic innervation of the accumbens promote the compulsive character of drug seeking in addicts by decreasing the value of natural rewards, diminishing cognitive control (choice), and enhancing glutamatorgic drive in response to drug-associated stimuli.
Journal ArticleDOI
Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.
Jeffrey W. Dalley,Tim D. Fryer,Laurent Brichard,Emma S J Robinson,David E. H. Theobald,Kristjan Lääne,Yolanda Pena,Emily R. Murphy,Yasmene B. Shah,Katrin C. Probst,Irina Abakumova,Franklin I. Aigbirhio,Hugh K. Richards,Young T. Hong,Jean-Claude Baron,Barry J. Everitt,Trevor W. Robbins +16 more
TL;DR: It is reported that a form of impulsivity in rats predicts high rates of intravenous cocaine self-administration and is associated with changes in dopamine function before drug exposure, and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences.
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