J
Jean-Matthieu Prot
Researcher at University of Technology of Compiègne
Publications - 26
Citations - 1252
Jean-Matthieu Prot is an academic researcher from University of Technology of Compiègne. The author has contributed to research in topics: Biochip & Liver cell. The author has an hindex of 16, co-authored 25 publications receiving 1114 citations. Previous affiliations of Jean-Matthieu Prot include Cornell University & University of Central Florida.
Papers
More filters
Journal ArticleDOI
Microfabricated Mammalian Organ Systems and Their Integration into Models of Whole Animals and Humans
Jong Hwan Sung,Mandy B. Esch,Jean-Matthieu Prot,Christopher J. Long,Alec S.T. Smith,James J. Hickman,Michael L. Shuler +6 more
TL;DR: The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems.
Journal ArticleDOI
Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow.
Mandy B. Esch,Jean-Matthieu Prot,Ying Wang,Paula G. Miller,Jose Ricardo Llamas-Vidales,Brian A. Naughton,Dawn R. Applegate,Michael L. Shuler +7 more
TL;DR: The findings support the theory that the increase in hepatic metabolic activity associated with fluidic flow is either activated by mechanisms other than shear sensing (for example increased opportunities for gas and metabolite exchange), or that it follows aShear sensing mechanism that does not depend on the direction of shear.
Journal ArticleDOI
How multi-organ microdevices can help foster drug development.
Mandy B. Esch,Alec S.T. Smith,Jean-Matthieu Prot,Carlota Oleaga,James J. Hickman,Michael L. Shuler +5 more
TL;DR: Studies in which multi-organ microdevices have been developed and used in a ways that demonstrate how the devices' capabilities can present unique opportunities for the study of drug action are reviewed.
Journal ArticleDOI
Behavior of HepG2/C3A cell cultures in a microfluidic bioreactor
TL;DR: The sensitivity of the HepG2/C3A cells to microfluidic culture conditions is highlighted and the potential for larger in vitro toxicity studies using microfluidity bioreactors is illustrated.
Journal ArticleDOI
Improvement of HepG2/C3a cell functions in a microfluidic biochip.
Jean-Matthieu Prot,Caroline Aninat,Laurent Griscom,Florence Razan,Céline Brochot,Christiane Guillouzo,Cécile Legallais,Anne Corlu,Eric Leclerc +8 more
TL;DR: Microfluidic biochip could and provide an important insight to exploring the xenobiotic's metabolism as a new pertinent tool for predicting cell toxicity and clearance of xenobiotics in vitro.