J
Jean-Michel Heard
Researcher at French Institute of Health and Medical Research
Publications - 18
Citations - 1910
Jean-Michel Heard is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Virus & Bone marrow. The author has an hindex of 14, co-authored 18 publications receiving 1864 citations. Previous affiliations of Jean-Michel Heard include Centre national de la recherche scientifique.
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Journal ArticleDOI
A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors.
Michèle Souyri,Isabelle Vigon,Jean-François Penciolelli,Jean-Michel Heard,Pierre Tambourin,Françoise Wendling +5 more
TL;DR: It is shown that in vitro infection of bone marrow cells with helper-free MPLV readily yields immortalized factor-independent hematopoietic cell lines of different lineages.
Journal ArticleDOI
Retroviral-mediated gene transfer into hepatocytes in vivo.
TL;DR: In rats, retroviral-mediated gene transfer with a surgical procedure in which the liver is temporarily excluded from the circulation and infected in vivo is combined to provide a feasible alternative to in vitro reimplantation of genetically modified hepatocytes.
Journal ArticleDOI
Human immunodeficiency virus type 1 entry into macrophages mediated by macropinocytosis.
Valérie Maréchal,Marie-Christine Prévost,Caroline Petit,Emmanuelle Perret,Jean-Michel Heard,Olivier Schwartz +5 more
TL;DR: Observations in human primary macrophages provide new insights into HIV-1 interactions with a cell target relevant to pathogenesis and may have implications for the design of soluble inhibitors aimed at interfering with the fusion or entry processes.
Journal ArticleDOI
Intracerebral administration of adeno-associated viral vector serotype rh.10 carrying human SGSH and SUMF1 cDNAs in children with mucopolysaccharidosis type IIIA disease: results of a phase I/II trial.
Marc Tardieu,Michel Zerah,Béatrice Husson,Stéphanie de Bournonville,Kumaran Deiva,Catherine Adamsbaum,Fanny Vincent,Michaël Hocquemiller,Christine Broissand,Valérie Furlan,Andrea Ballabio,Alessandro Fraldi,Ronald G. Crystal,Thomas Baugnon,Thomas Roujeau,Jean-Michel Heard,Olivier Danos +16 more
TL;DR: Four children (Patients 1–3, aged between 5.5 and 6 years; Patient 4 aged 2 years 8 months) received intracerebral injections of an adeno-associated viral vector serotype rh.10-SGSH-IRES-SUMF1 vector in a phase I/II clinical trial, with promising results.
Journal ArticleDOI
Antiviral Activity of the Proteasome on Incoming Human Immunodeficiency Virus Type 1
Olivier Schwartz,Valérie Maréchal,Bertrand Friguet,Fernando Arenzana-Seisdedos,Jean-Michel Heard +4 more
TL;DR: It is shown that treatment of target cells with the proteasome inhibitors MG132 and lactacystin increased the efficiency of HIV infection and degradation of incoming viral proteins by the proteAsome represents an early intracellular defense against infection.