J
Jean-Michel Wieruszeski
Researcher at Centre national de la recherche scientifique
Publications - 179
Citations - 6982
Jean-Michel Wieruszeski is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Glycan & Oligosaccharide. The author has an hindex of 47, co-authored 179 publications receiving 6701 citations. Previous affiliations of Jean-Michel Wieruszeski include Lille University of Science and Technology & University of the Sciences.
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Journal ArticleDOI
Waxy Chlamydomonas reinhardtii: monocellular algal mutants defective in amylose biosynthesis and granule-bound starch synthase activity accumulate a structurally modified amylopectin.
Brigitte Delrue,Thierry Fontaine,Françoise H. Routier,André Decq,Jean-Michel Wieruszeski,N Van Den Koornhuyse,Marie-Lise Maddelein,B Fournet,Steven G. Ball +8 more
TL;DR: It is proposed that the waxy gene product conditions not only the synthesis of amylose from endosperm storage tissue in higher-plant amyloplasts but also that ofAmylose and a fraction of amyopectin in all starch-accumulating plastids.
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Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolyl cis/trans Isomerase Activity of Cyclophilins A and B
Xavier Hanoulle,Aurélie Badillo,Jean-Michel Wieruszeski,Dries Verdegem,Isabelle Landrieu,Ralf Bartenschlager,François Penin,Guy Lippens +7 more
TL;DR: NMR heteronuclear exchange spectroscopy yielded direct evidence that many proline residues in NS5A-D2 form a valid substrate for the enzymatic peptidyl-prolyl cis/trans isomerase (PPIase) activity of CypA and CypB.
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Use of a water flip-back pulse in the homonuclear NOESY experiment.
TL;DR: It is shown experimentally that a simple modification to the WATERGATE water suppression scheme results in a 20% gain in intensity for all signals when using a relaxation delay of 1.5 s, and that avoiding a semisaturated state for the water magnetization allows the amide protons as well as other proton resonances to relax to equilibrium with their proper relaxation time.
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Toward an understanding of the biogenesis of the starch granule. Evidence that Chlamydomonas soluble starch synthase II controls the synthesis of intermediate size glucans of amylopectin.
Thierry Fontaine,Christophe D'Hulst,Marie-Lise Maddelein,Françoise H. Routier,T.M. Pépin,André Decq,Jean-Michel Wieruszeski,Brigitte Delrue,N Van Den Koornhuyse,J.P. Bossu +9 more
TL;DR: The results suggest that a soluble starch synthase may be necessary for the synthesis or maintenance of intermediate size glucans that are the main component of the branched clusters of amylopectin.
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Structure of an exocellular polysaccharide produced by Streptococcus thermophilus
Thierry Doco,Jean-Michel Wieruszeski,Bernard Fournet,Didier Carcano,Patricia Ramos,Alain Loones +5 more
TL;DR: Streptococcus thermophilus strains grown on skimmed milk produced a viscosifying, exocellular, and water-soluble polysaccharide which contains D-glucose, D-galactose, and N-acetyl-D-Galactosamine in the ratio of 1:2:1.