J
Jean-Paul Latgé
Researcher at Pasteur Institute
Publications - 355
Citations - 32286
Jean-Paul Latgé is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Aspergillus fumigatus & Aspergillosis. The author has an hindex of 91, co-authored 343 publications receiving 29152 citations. Previous affiliations of Jean-Paul Latgé include University of Crete & University of Perugia.
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Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways.
Mariolina Bruno,Intan M.W. Dewi,Vicky Matzaraki,Rob ter Horst,Marina Pekmezovic,Berenice Rösler,Laszlo Groh,Rutger J. Röring,Vinod Kumar,Vinod Kumar,Yang Li,Yang Li,Agostinho Carvalho,Mihai G. Netea,Mihai G. Netea,Jean-Paul Latgé,Mark S. Gresnigt,Mark S. Gresnigt,Frank L. van de Veerdonk +18 more
TL;DR: In this article, the authors used unbiased transcriptional profiling in PBMCs exposed to the fungal species causing these infections, finding a core host response in healthy individuals that may govern effective fungal clearance: it consists of 156 transcripts, involving canonical and non-canonical immune pathways.
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The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation Components
Shriya Raj,Karthik Krishnan,David S. Askew,Olivier Helynck,Peggy Suzanne,Aureslien Lesnard,Sylvain Rault,Ute Zeidler,Christophe d'Enfert,Jean-Paul Latgé,Hélène Munier-Lehmann,Hélène Munier-Lehmann,Cosmin Saveanu +12 more
TL;DR: The data from this chemogenomic analysis demonstrate that sr7575 exerts its antifungal activity by disrupting ER protein quality control in a manner that requires ERAD intervention but bypasses the need for the canonical UPR, indicating a specific vulnerability of fungal organisms that might be exploited for antif fungus drug development.
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Phylogenetic and Functional Analysis of Aspergillus fumigatus MGTC, a Fungal Protein Homologous to a Bacterial Virulence Factor
Amandine Gastebois,Anne-Beatrice Blanc Potard,Simonetta Gribaldo,Rémi Beau,Jean-Paul Latgé,Isabelle Mouyna +5 more
TL;DR: The data show that the A. fumigatus MGTC (AfuMgtC) protein does not have the same function as the bacterial MgtC proteins.
Journal ArticleDOI
RNA-dependent sterol aspartylation in fungi.
Nathaniel Yakobov,Frédéric Fischer,Nassira Mahmoudi,Yusuke Saga,Christopher D. Grube,Hervé Roy,Bruno Senger,Guillaume Grob,Shunsuke Tatematsu,Daisuke Yokokawa,Isabelle Mouyna,Jean-Paul Latgé,Harushi Nakajima,Tetsuo Kushiro,Hubert Dominique Becker +14 more
TL;DR: The discovery of ergosteryl-3β-O-l-aspartate (Erg-Asp), a conjugated sterol that is produced by the tRNA-dependent addition of aspartate to the 3β-OH group of ergosterol, the major sterol found in fungal membranes is reported here.