J
Jean-Pierre Galy
Researcher at Université Paul Cézanne Aix-Marseille III
Publications - 103
Citations - 1217
Jean-Pierre Galy is an academic researcher from Université Paul Cézanne Aix-Marseille III. The author has contributed to research in topics: Acridine & Carbon-13 NMR. The author has an hindex of 20, co-authored 103 publications receiving 1167 citations. Previous affiliations of Jean-Pierre Galy include Centre national de la recherche scientifique & Spanish National Research Council.
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Synthesis and antileishmanial activity of (1,3-benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives.
F. Delmas,Antonio Avellaneda,Carole Di Giorgio,Maxime Robin,Erik De Clercq,P. Timon-David,Jean-Pierre Galy +6 more
TL;DR: (1,3-Benzothiazol-2-yl) amino-9-(10H)-acridinone derivatives were synthesized via a procedure based on the Ullman reaction and were assessed for their in vitro antileishmanial and anti-HIV activities.
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Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine.
TL;DR: In this article, diaminoacridinic derivatives obtained from proflavine and N-(6-amino-3-acridinyl)acetamide were synthesised and assessed for their cytotoxic and antileishmanial activities.
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In Vitro Activities of Position 2 Substitution-Bearing 6-Nitro- and 6-Amino-Benzothiazoles and Their Corresponding Anthranilic Acid Derivatives against Leishmania infantum and Trichomonas vaginalis
F. Delmas,Carole Di Giorgio,Maxime Robin,Nadine Azas,Monique Gasquet,Claire Detang,Muriel Costa,P. Timon-David,Jean-Pierre Galy +8 more
TL;DR: Experiments established that compound C11 could improve host-protective mechanisms against Leishmania by preventing parasite internalization by macrophages and stimulating NO production, by means of a mechanism synergistically enhanced by the presence of gamma interferon.
Short communication Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine
TL;DR: Two new series of diaminoacridinic derivatives obtained from proflavine and N-amino-3-acridinyl)acetamide demonstrated highly specific antileishmanial properties against the intracellular amastigote form of the parasite, suggesting that symmetric conformations could preferentially interfere with Leishmania metabolism.
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In Vitro Activities of 7-Substituted 9-Chloro and 9-Amino-2-Methoxyacridines and Their Bis- and Tetra-Acridine Complexes against Leishmania infantum
Carole Di Giorgio,F. Delmas,Nathalie Filloux,Maxime Robin,Laetitia Seferian,Nadine Azas,Monique Gasquet,Muriel Costa,P. Timon-David,Jean-Pierre Galy +9 more
TL;DR: The results clearly confirmed that several compounds of the 2-methoxyacridine series, together with their corresponding dimeric and tetrameric derivatives, had strong in vitro antiparasitic properties, and suggested that acridine compounds could be considered multitarget drugs.