다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications

1. Introduction 20642. Synthesis of Magnetic Nanoparticles 20662.1. Classical Synthesis by Coprecipitation 20662.2. Reactions in Constrained Environments 20682.3. Hydrothermal and High-TemperatureReactions20692.4. Sol-Gel Reactions 20702.5. Polyol Methods 20712.6. Flow Injection Syntheses 20712.7. Electrochemical Methods 20712.8. Aerosol/Vapor Methods 20712.9. Sonolysis 20723. Stabilization of Magnetic Particles 20723.1. Monomeric Stabilizers 20723.1.1. Carboxylates 20733.1.2. Phosphates 20733.2. Inorganic Materials 20733.2.1. Silica 20733.2.2. Gold 20743.3. Polymer Stabilizers 20743.3.1. Dextran 20743.3.2. Polyethylene Glycol (PEG) 20753.3.3. Polyvinyl Alcohol (PVA) 20753.3.4. Alginate 20753.3.5. Chitosan 20753.3.6. Other Polymers 20753.4. Other Strategies for Stabilization 20764. Methods of Vectorization of the Particles 20765. Structural and Physicochemical Characterization 20785.1. Size, Polydispersity, Shape, and SurfaceCharacterization20795.2. Structure of Ferro- or FerrimagneticNanoparticles20805.2.1. Ferro- and Ferrimagnetic Nanoparticles 20805.3. Use of Nanoparticles as Contrast Agents forMRI20825.3.1. High Anisotropy Model 20845.3.2. Small Crystal and Low Anisotropy EnergyLimit20855.3.3. Practical Interests of Magnetic NuclearRelaxation for the Characterization ofSuperparamagnetic Colloid20855.3.4. Relaxation of Agglomerated Systems 20856. Applications 20866.1. MRI: Cellular Labeling, Molecular Imaging(Inﬂammation, Apoptose, etc.)20866.2.

Magnetic Iron Oxide Nanoparticles: Synthesis, Stabilization, Vectorization, Physicochemical Characterizations, and Biological Applications

TOPICAL REVIEW: Applications of magnetic nanoparticles in biomedicine

Nanoparticles containing magnetic materials, such as magnetite (Fe3O4), are particularly useful for imaging and separation techniques. As these nanoparticles are generally considered to be biologically and chemically inert, they are typically coated with metal catalysts, antibodies or enzymes to increase their functionality as separation agents. Here, we report that magnetite nanoparticles in fact possess an intrinsic enzyme mimetic activity similar to that found in natural peroxidases, which are widely used to oxidize organic substrates in the treatment of wastewater or as detection tools. Based on this finding, we have developed a novel immunoassay in which antibody-modified magnetite nanoparticles provide three functions: capture, separation and detection. The stability, ease of production and versatility of these nanoparticles makes them a powerful tool for a wide range of potential applications in medicine, biotechnology and environmental chemistry.

Intrinsic peroxidase-like activity of ferromagnetic nanoparticles

Cell Surveillance Using Magnetic Resonance Imaging

https://link.springer.com/content/pdf/10.1186%2F1532-429X-10-S1-A175.pdf

1050 Applicability of perfusion MRI in monitoring cell-based therapy in a rabbit hindlimb ischemia model

The present invention is directed to an MRI technique to assess tumor malignancy non-invasively. It is based on the principle that most malignant epithelial tumor cells express mucins that are heavily underglyocsylated. This phenomenon of aberrant expression has been well-documented in the literature. When benign tumor cells having normal mucin glycosylation with CEST MRI are imaged a strong CEST MRI signal effect is seen. When tumor cells lose their glycans and become malignant, the difference in MRI CEST signal is detectable. Thus, the intrinsic properties of tumor cell surface mucin glycosylation can be used as a surrogate marker for predicting tumor malignancy. This can be accomplished without injecting exogenous probes or labels, which have their own problems in terms of clinical approval, cost, and pharmacokinetics of binding to all tumor cells in question. Normal tissue can be used as a reference in determining changes in contrast associated with malignancy.

Label-free mr imaging of tumor malignancy

Cell transplantation, similar to organ transplantation, has the ability to provide dynamic treatments to patients that can keep pace with the demands of their lives, yet most cell transplantation therapies do not succeed in treating the patient. Transplant imaging has been developed to explore why cell transplantation can fail as a therapy. However, to date, transplant imaging has primarily focused on potential issues at the cellular level, assessing the number and/or location of transplanted cells present after administration. Lack of survival and migration data are only two of the reasons why cell transplantation can fail as a therapy. Imaging the molecular environment can interrogate the other limitations of candidate therapies: misdirected differentiation, unstable phenotype, reduced functionality, and non-ideal cellular interactions. Detecting these unintended outcomes faster using molecular imaging strategies will allow clinicians to make therapeutic adjustments before failure occurs. More informative imaging strategies will also permit tailoring cell transplants into more robust, patient-specific therapies for personalized medicine.

Jeff W.M. Bulte

Papers

Cell Surveillance Using Magnetic Resonance Imaging

1050 Applicability of perfusion MRI in monitoring cell-based therapy in a rabbit hindlimb ischemia model

Label-free mr imaging of tumor malignancy

Molecular Considerations in Cell Transplant Imaging

MR imaging and the development of stem cell-based therapies