J
Jeffery G. Saven
Researcher at University of Pennsylvania
Publications - 119
Citations - 5995
Jeffery G. Saven is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Protein structure & Protein design. The author has an hindex of 45, co-authored 116 publications receiving 5524 citations. Previous affiliations of Jeffery G. Saven include UPRRP College of Natural Sciences & Japan Atomic Energy Research Institute.
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Journal ArticleDOI
Solvophobically Driven Folding of Nonbiological Oligomers
TL;DR: An aromatic hydrocarbon backbone is described that spontaneously acquires a stable helical conformation having a large cavity and is sensitive to chain length, solvent quality, and temperature.
Journal ArticleDOI
Cooperative Conformational Transitions in Phenylene Ethynylene Oligomers: Chain-Length Dependence
TL;DR: Fluorescence quenching has been used to study the cooperative conformational transition in a series of oligo(phenylene ethynylene)s having tri(ethylene glycol) monomethyl ether side chains as discussed by the authors.
Journal ArticleDOI
Computational design of a protein crystal
Christopher J. Lanci,Christopher M. MacDermaid,Seung-gu Kang,Rudresh Acharya,Benjamin North,Xi Yang,X. Jade Qiu,William F. DeGrado,Jeffery G. Saven +8 more
TL;DR: A computational approach is presented for the design of proteins that self-assemble in three dimensions to yield macroscopic crystals and has potential applications to the de novo design of nanostructured materials and to the modification of natural proteins to facilitate X-ray crystallographic analysis.
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Helical wrapping of single-walled carbon nanotubes by water soluble poly(p-phenyleneethynylene).
Youn K. Kang,One Sun Lee,Pravas Deria,Sang Hoon Kim,Tae Hong Park,Dawn A. Bonnell,Jeffery G. Saven,Michael J. Therien +7 more
TL;DR: Data reveal that the interaction of PPES with SWNTs gives rise to a self-assembled superstructure in which a polymer monolayer helically wraps the nanotube surface; the observed PPES pitch length confirms structural predictions made via molecular dynamics simulations.
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Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor.
Frank V. Cochran,Sophia P. Wu,Wei Wang,Vikas Nanda,Jeffery G. Saven,Michael J. Therien,William F. DeGrado +6 more
TL;DR: In this article, a tetrameric, D2-symmetric backbone scaffold was constructed to encapsulate two DPP−Fe(III) units through bis(His) coordination.