J
Jeffrey B. Boord
Researcher at Vanderbilt University Medical Center
Publications - 9
Citations - 1300
Jeffrey B. Boord is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Insulin resistance & Metabolic syndrome. The author has an hindex of 7, co-authored 9 publications receiving 1243 citations.
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Journal ArticleDOI
Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis.
Liza Makowski,Jeffrey B. Boord,Kazuhisa Maeda,Vladimir R. Babaev,K. Teoman Uysal,Maureen A. Morgan,Rex A. Parker,Jill Suttles,Sergio Fazio,Gökhan S. Hotamisligil,MacRae F. Linton +10 more
TL;DR: Through its distinct actions in adipocytes and macrophages, aP2 provides a link between features of the metabolic syndrome and could be a new therapeutic target for the prevention of atherosclerosis.
Journal ArticleDOI
Combined Adipocyte-Macrophage Fatty Acid–Binding Protein Deficiency Improves Metabolism, Atherosclerosis, and Survival in Apolipoprotein E–Deficient Mice
Jeffrey B. Boord,Kazuhisa Maeda,Kazuhisa Maeda,Liza Makowski,Vladimir R. Babaev,Sergio Fazio,MacRae F. Linton,MacRae F. Linton,Gökhan S. Hotamisligil +8 more
TL;DR: Combined aP2 and mal1 deficiency improved glucose and lipid metabolism, reduced atherosclerosis, and improved survival in apoE−/− mice, making these proteins important therapeutic targets for the prevention of the cardiovascular consequences of the metabolic syndrome.
Journal ArticleDOI
Adipocyte Fatty Acid–Binding Protein, aP2, Alters Late Atherosclerotic Lesion Formation in Severe Hypercholesterolemia
Jeffrey B. Boord,Kazuhisa Maeda,Liza Makowski,Vladimir R. Babaev,Sergio Fazio,MacRae F. Linton,Gökhan S. Hotamisligil +6 more
TL;DR: An important role for aP2 expression in the advanced stages of atherosclerotic lesion formation is demonstrated, demonstrating an important physiological link between different features of the metabolic syndrome and is a potential target for therapy of Atherosclerosis.
Journal ArticleDOI
Cytoplasmic fatty acid-binding proteins: emerging roles in metabolism and atherosclerosis.
TL;DR: Interestingly, expression of aP2 by the macrophage promotes atherogenesis, thus providing a link between insulin resistance, intracellular fatty acid disposition, and foam cell formation, and the FABPs are promising targets for the treatment of dyslipidemia, insulin resistance and atherosclerosis in humans.