J
Jeffrey M. Peters
Researcher at Pennsylvania State University
Publications - 217
Citations - 21665
Jeffrey M. Peters is an academic researcher from Pennsylvania State University. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Receptor. The author has an hindex of 74, co-authored 214 publications receiving 20405 citations. Previous affiliations of Jeffrey M. Peters include Lawrence Livermore National Laboratory & National Institutes of Health.
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Journal ArticleDOI
Involvement of the peroxisome proliferator-activated receptor α in regulating long-chain acyl-CoA thioesterases
Mary C. Hunt,Per J.G. Lindquist,Jeffrey M. Peters,Frank J. Gonzalez,Ulf Diczfalusy,Stefan E.H. Alexson +5 more
TL;DR: Northern blot analysis shows that the induction of these thioesterases by clofibrate is mediated through a strictly PPARalpha-dependent mechanism, and demonstrates that the nutritional regulation of the thioestersases involves the PPAR alpha and other signaling pathways responsible for activation and repression.
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Evidence against the peroxisome proliferator-activated receptor α (PPARα) as the mediator for polyunsaturated fatty acid suppression of hepatic L-pyruvate kinase gene transcription
David A. Pan,Michelle K. Mater,Annette P. Thelen,Jeffrey M. Peters,Frank J. Gonzalez,Donald B. Jump +5 more
TL;DR: It is suggested that other intermediary factors are involved in both the PUFA and PPARalpha regulation of L-PK gene transcription.
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In Vivo Regulation of Hepatitis B Virus Replication by Peroxisome Proliferators
Luca G. Guidotti,Carrie M. Eggers,Anneke K. Raney,Susan Y. Chi,Jeffrey M. Peters,Frank J. Gonzalez,Alan McLachlan +6 more
TL;DR: It appears that very modest alterations in transcription can, under certain circumstances, result in relatively large increases in HBV replication inHBV transgenic mice.
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Dissecting the role of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) in colon, breast, and lung carcinogenesis
TL;DR: The prevailing evidence would suggest that targeting PPARβ/δ is not only safe but could have anti-carcinogenic protective effects, and this review examines studies reporting the role of PPARδ in colon, breast, and lung cancers.
Journal ArticleDOI
Cellular and Pharmacological Selectivity of the Peroxisome Proliferator-Activated Receptor-β/δ Antagonist GSK3787
Prajakta S. Palkar,Michael G. Borland,Simone Naruhn,Christina H. Ferry,Christina Lee,Ugir Hossain Sk,Arun Sharma,Shantu Amin,Iain A. Murray,Cherie R. Anderson,Gary H. Perdew,Frank J. Gonzalez,Rolf Müller,Jeffrey M. Peters +13 more
TL;DR: It is demonstrated that GSK3787 can antagonize PPARβ/δ in vivo, thus providing a new strategy to delineate the functional role of a receptor with great potential as a therapeutic target for the treatment and prevention of disease.