Lei Chen

TL;DR: It is suggested that the 1.5-fold increase in dosage of DSCR1 and DYRK1A cooperatively destabilizes a regulatory circuit, leading to reduced NFATc activity and many of the features of Down's syndrome, and the destabilization of regulatory circuits can underlie human disease.

TL;DR: This work purify two proteins encoded by separate genes that represent the pre-existing and cytosolic components of NF-AT, indicating that distinct signalling pathways converge onNF-ATc to regulate its function.

TL;DR: It is found that BAF53a repression is mediated by sequences in the 3′ untranslated region corresponding to the recognition sites for miR-9* and miR -124, which are selectively expressed in post-mitotic neurons.

TL;DR: It is shown that BAF complexes are required for the self-renewal and pluripotency of mouse ES cells but not for the proliferation of fibroblasts or other cells, suggesting that esBAF complexes are specialized to interact with ES cell-specific regulators, providing a potential explanation for the requirement of BAF complex in pluripOTency.

TL;DR: It is shown that calcineurin function is transiently required between E7.5 and E8.5, which initiates the later cross-talk between vessels and surrounding tissues that pattern the vasculature.