Showing papers by "Jelena Mirkovic published in 2023"
TL;DR: In this article , the mesonephric-like adenocarcinomas (MLAs) of the female genital tract were found in five different individuals, and they were classified into five groups.
Abstract: To report novel observations in five mesonephric‐like adenocarcinomas (MLAs) of the female genital tract.
2 citations
TL;DR: In this article , the authors aim to increase academic exposure to these research areas and raise awareness around educating the cybersecurity workforce, and propose a framework to train a cybersecurity workforce to inspect and verify the functionality and security of these devices.
Abstract: Many topics in the hardware security community, such as physical inspection and attacks, are still in early stages of research. As the semiconductor industry continues to advance towards higher volume production, there is an increasing demand to inspect and verify the functionality and security of these devices. This article aims to increase academic exposure to these research areas and raise awareness around educating the cybersecurity workforce.
TL;DR: In this paper , a phytoplasma strain infecting sugar beet in Saxony-Anhalt, Germany was classified into a new subgroup designated as 16SrXII-P. The MLSA of non-ribosomal genes of this strain showed that it is significantly different from the reference and all previously reported 'Ca. P. solani' strains including strain from western Germany.
Abstract: Two phloem-limited pathogens, 'Candidatus Arsenophonus phytopathogenicus' and 'Candidatus Phytoplasma solani', threaten sugar beet production in France, Switzerland and Germany. Previous studies of these pathogens in Germany had focused on its western and southern regions, leaving a knowledge gap about eastern Germany. Despite their importance, this study is the first to investigate phytoplasmas in sugar beet in Saxony-Anhalt, Germany. A phytoplasma strain related to 'Ca. P. solani' is found predominant in Saxony-Anhalt, unlike in France, where 'Ca. P. solani' has a minor role compared to 'Ca. A. phytopathogenicus'. The phytoplasma strain infecting sugar beet in Saxony-Anhalt was classified into a new subgroup designated as 16SrXII-P. The MLSA of non-ribosomal genes of the novel phytoplasma strain showed that it is significantly different from the reference and all previously reported 'Ca. P. solani' strains including strain from western Germany. Analyses of sugar beet samples from previous years confirmed the presence of the 16SrXII-P strain in sugar beet as early as 2020, and also in Bavaria in southern Germany. Based on 16S rDNA analysis, 'Ca. A. phytopathogenicus' in Saxony-Anhalt is identical to strains in sugar beet in other parts of Germany and France, as well as to a strain in potato from Germany. The presence and prevalence of two phytoplasmas in sugar beet in Germany, suggest that more attention should be directed towards understanding phytoplasma infection in sugar beet in this country.
TL;DR: In this article , targeted genomic sequencing and immunohistochemical analysis was carried out on seven DEC-HG and four DEC-LG, including undifferentiated and differentiated components, both showed a similar frequency and spectrum of mutations.
Abstract: AIMS
Our understanding of dedifferentiated endometrial carcinoma (DEC), a rare and aggressive malignancy, mainly reflects undifferentiated carcinomas (UC) arising in the setting of low-grade endometrial cancer (DEC-LG). However, cases of UC arising in the setting of high-grade EC (DEC-HG) have been noted in the literature. Our knowledge of the genomics of DEC-HG is limited. To characterise the molecular landscape of DEC-HC, targeted genomic sequencing and immunohistochemical analysis was carried out on seven DEC-HG and four DEC-LG.
METHODS AND RESULTS
DEC-HG and DEC-LG, including undifferentiated and differentiated components, both showed a similar frequency and spectrum of mutations. ARID1A mutations were identified in 6/7 (86%) DEC-HG and 4/4 (100%) DEC-LG, while SMARCA4 mutations were present in 4/7 (57%) DEC-HG and in 1/4 (25%) DEC-LG. Concurrent SMARCA4/BRG1 protein loss by immunohistochemistry was observed in 3/4 and 1/1 SMARCA4 mutated DEC-HG and DEC-LG, respectively. Neither genomic alterations nor protein loss in SMARCB1/INI1 were observed in any of our cases. TP53 mutations were detected in 4/7 (57%) DEC-HG and in 2/4 (50%) DEC-LG, while mutation-pattern p53 immunohistochemistry expression was observed in 2/7 (29%) DEC-HG and none of the DEC-LG. MLH1 mutations were observed in 1/7 (14%) DEC-HG and 1/4 (25%) DEC-LG. MSH2 and MSH6 mutations were each detected in 1/7 (14%) DEC-HG, but neither was associated with corresponding loss of protein expression.
CONCLUSION
The findings support expanding the definition of DEC to include DEC-HG, a previously under-recognised phenomenon with genomic similarities to DEC-LG.
Proceedings Article•
TL;DR: Aura as mentioned in this paper is a production-level synthesis system for datacenter routing policies, which consists of a high-level language, called RPL, that expresses the desired behavior and a compiler that automatically generates switch configurations.
Abstract: Configuration of production datacenters is challenging due to their scale (many switches), complexity (specific policy requirements), and dynamism (need for many configuration changes). This paper introduces Aura, a production-level synthesis system for datacenter routing policies. It consists of a high-level language, called RPL, that expresses the desired behavior and a compiler that automatically generates switch configurations. Unlike existing approaches, which generate full network configuration for a static policy, Aura is built to support frequent policy and network changes. It generates and deploys multiple parallel policy collections, in a way that supports smooth transitions between them without disrupting live production traffic. Aura has been deployed for over two years in Meta datacenters and has greatly improved our management efficiency. We also share our operational requirements and experiences, which can potentially inspire future research.
TL;DR: The most common eye structure affected are pathological findings in anterior chamber (n = 160.56%), which are mainly related to hyphemia as discussed by the authors . But men are more likely to be injured more often than women.
Abstract: Introduction/Objective. Ocular trauma is a globally important cause of visual
impairment. The aim of our study was to analyses demographic,
epidemiological and clinical characteristics of blunt ocular trauma.
Methods. The retrospective study enrolled patients with blunt ocular trauma,
hospitalized at the Eye Clinic, University Clinical Center of Serbia in
Belgrade in a four-year period (2018-2022). Demographic characteristics,
mechanism of injury, best corrected visual acuity on admission and discharge
and injured eye structure were analyzed. Results. Out of 283 patients, the
majority (n = 233.82%) were men. People aged 61 and over (n = 82.29%) were
at greatest risk for blunt ocular trauma. Injuries from splitting wood (n =
78.28%) and various blunt tools and objects (n = 70.25%) were the most
common mechanism in the entire study group, both in men and in women. Visual
acuity on admission was better than 0.6 in 147 (52%) patients and at
discharge in 185 (65%). The most common eye structure affected are
pathological findings in anterior chamber (n = 160.56%), which are mainly
related to hyphemia. Conclusion. Present study showed that blunt ocular
trauma affects all age groups, but most often elderly and children. Men are
injured more often than women. Splitting wood and manipulating blunt tools
and objects are activities with the highest risk of blunt ocular trauma.