J
Jan Böhm
Researcher at University of Eastern Finland
Publications - 60
Citations - 1735
Jan Böhm is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Cancer & Colorectal cancer. The author has an hindex of 22, co-authored 48 publications receiving 1422 citations.
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Journal ArticleDOI
Prognostic value of hyaluronan expression in non-small-cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma.
Risto Pirinen,Raija Tammi,Markku Tammi,Pasi Hirvikoski,Jyrki Parkkinen,Risto T. Johansson,Jan Böhm,Sinikka Hollmen,Veli-Matti Kosma +8 more
TL;DR: The results indicate that the frequency and intensity of HA has a significant prognostic value in NSCLC, particularly when the histological subtypes are analyzed as separate entities.
Journal ArticleDOI
Exome sequencing reveals frequent inactivating mutations in ARID1A, ARID1B, ARID2 and ARID4A in microsatellite unstable colorectal cancer.
Tatiana Cajuso,Ulrika A. Hänninen,Johanna Kondelin,Alexandra E. Gylfe,Tomas Tanskanen,Riku Katainen,Esa Pitkänen,Heikki Ristolainen,Eevi Kaasinen,Minna Taipale,Minna Taipale,Jussi Taipale,Jussi Taipale,Jan Böhm,Laura Renkonen-Sinisalo,Jukka-Pekka Mecklin,Heikki Järvinen,Sari Tuupanen,Outi Kilpivaara,Pia Vahteristo +19 more
TL;DR: The results indicate that in addition to ARID1A, other members of the ARID gene family may play a role in MSI CRC, and the mutations were distributed along the entire length of the gene, thus distinguishing them from typical MSI target genes previously described.
Journal ArticleDOI
Combination of microsatellite instability and BRAF mutation status for subtyping colorectal cancer.
Toni T. Seppälä,Jan Böhm,Marjukka Friman,Laura Lahtinen,Ville Väyrynen,T K E Liipo,Ari Ristimäki,Matti V. Kairaluoma,Ilmo Kellokumpu,Teijo Kuopio,Mecklin Jp +10 more
TL;DR: Microsatellite instable tumours were associated with better prognosis compared with MSS and BRAFV600E subtype was a favourable prognostic factor compared with the MSS/BRAF wild-type subtype.
Journal ArticleDOI
Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer
Kati Kämpjärvi,Netta Mäkinen,Outi Kilpivaara,Johanna Arola,H-R Heinonen,Jan Böhm,Omar Abdel-Wahab,Heli J. Lehtonen,Liisa M. Pelttari,Miika Mehine,H. Schrewe,Heli Nevanlinna,Ross L. Levine,Peter Hokland,Tom Böhling,Mecklin Jp,Ralf Bützow,Lauri A. Aaltonen,Pia Vahteristo +18 more
TL;DR: Somatic MED12 exon 2 mutations were observed in uterine leiomyosarcomas, suggesting that a subgroup of these malignant tumours may develop from a leioma precursor.
Journal ArticleDOI
Versican in nonsmall cell lung cancer: relation to hyaluronan, clinicopathologic factors, and prognosis
Risto Pirinen,Tero Leinonen,Jan Böhm,Risto T. Johansson,K M Ropponen,Eero J. Kumpulainen,Veli-Matti Kosma +6 more
TL;DR: Investigating the expression and prognostic role of versican in 212 patients with resected nonsmall cell lung cancer indicates that increased stromal versican is related to higher tumor recurrence rate and more advanced disease.