J
Jelver Sierra
Researcher at Universidade Federal de Santa Catarina
Publications - 27
Citations - 688
Jelver Sierra is an academic researcher from Universidade Federal de Santa Catarina. The author has contributed to research in topics: Gut flora & Medicine. The author has an hindex of 12, co-authored 23 publications receiving 460 citations. Previous affiliations of Jelver Sierra include University of Antioquia.
Papers
More filters
Journal ArticleDOI
Higher Fecal Short-Chain Fatty Acid Levels Are Associated with Gut Microbiome Dysbiosis, Obesity, Hypertension and Cardiometabolic Disease Risk Factors
Jacobo de la Cuesta-Zuluaga,Noel T. Mueller,Rafael Álvarez-Quintero,Eliana P. Velásquez-Mejía,Jelver Sierra,Vanessa Corrales-Agudelo,Jenny A. Carmona,José M. Abad,Juan S. Escobar +8 more
TL;DR: Higher SCFA excretion was associated with evidence of gut dysbiosis, gut permeability, excess adiposity, and cardiometabolic risk factors, and studies assessing both fecal and circulating SCFAs are needed.
Journal ArticleDOI
Proatherogenic macrophage activities are targeted by the flavonoid quercetin.
Oscar J. Lara-Guzmán,Jorge H. Tabares-Guevara,Yudy M. León-Varela,Rafael Álvarez,Miguel Roldan,Jelver Sierra,Julián Londoño-Londoño,José R. Ramírez-Pineda +7 more
TL;DR: It is demonstrated that quercetin interferes with both key proatherogenic activities of macrophages, namely foam cell formation and pro-oxidant/proinflammatory responses, and these effects may explain the atheroprotective properties of this common flavonoid.
Journal ArticleDOI
Multifunctional hybrid nanoparticles as magnetic delivery systems for siRNA targeting the HER2 gene in breast cancer cells.
Tatiane Cristofolini,Milene Dalmina,Jelver Sierra,Adny Henrique Silva,André A. Pasa,Frederico Pittella,Tânia Beatriz Creczynski-Pasa +6 more
TL;DR: A magnetic hybrid nanostructure composed of iron oxide nanoparticles coated with caffeic acid and stabilized by layers of calcium phosphate and PEG-polyanion block copolymer was prepared for incorporation of siRNA, inducing HER2 gene silencing in HER2-positive breast cancer patients.
Journal ArticleDOI
Synthesis, cytotoxicity and antiviral activity of podophyllotoxin analogues modified in the E-ring
M. Angeles Castro,José M. Miguel del Corral,Marina Gordaliza,M. Antonia Gomez‐Zurita,M. Luz de la Puente,Liliana Betancur-Galvis,Jelver Sierra,Arturo San Feliciano +7 more
TL;DR: Several podophyllotoxin derivatives modified in the E-ring were prepared and evaluated for their cytotoxicity on four neoplastic cell lines and for their antiherpetic activity against Herpes simplex virus type II.
Journal ArticleDOI
Citrus juice extraction systems: effect on chemical composition and antioxidant activity of clementine juice.
Rafael Álvarez,Catarina Pedro Pássaro Carvalho,Jelver Sierra,Oscar Lara,David Andrés Velásquez Cardona,Julián Londoño-Londoño +5 more
TL;DR: The results showed that juice extracted by the former method presented higher yields and hesperidin content, which was related to higher antioxidant activity, demonstrated by ORAC and LDL assays.