Jenifer R. Prosperi

TL;DR: In this paper, β-catenin expression level was significantly reduced in two human triple-negative breast cancer cell lines, MDA-MB-231 and HCC38, using lentiviral delivery of small hairpin RNAs (shRNAs).

TL;DR: The data suggest that β-catenin is required for triple-negative breast cancer development by controlling numerous tumor-associated properties, such as migration, stemness, anchorage-independent growth and chemosensitivity.

TL;DR: This review will provide an overview of the current understanding of Wnt/beta-catenin pathway involvement in regulating normal breast development and morphogenesis, the generation of WNT/ Beta-Catenin-dependent GEM models of human breast cancer, upregulation of signaling in human breast cancers and the compelling therapeutic strategies aimed at targeting the Wnt / beta-catanin pathway that show promising anti-tumor activity.

TL;DR: This review article seeks to provide information about the common cancers in which taxanes are used and resistance occurs, in order to find targetable mechanisms that can be used to overcome resistance, and identifies gaps in knowledge surrounding taxane resistance.

TL;DR: It is demonstrated that Cox-2 directly regulates gene expression of specific aromatase promoter regions and regulates aromatases enzyme activity, which may be useful in significantly limiting aromat enzyme activity and proliferation of human breast tumor cells regardless of the presence of Cox- 2.