J
Jennifer A. DiNieri
Researcher at Harvard University
Publications - 4
Citations - 1255
Jennifer A. DiNieri is an academic researcher from Harvard University. The author has contributed to research in topics: Stimulation & Agonist. The author has an hindex of 4, co-authored 4 publications receiving 1187 citations.
Papers
More filters
Journal ArticleDOI
Mania-like behavior induced by disruption of CLOCK.
Kole T. Roybal,David Theobold,Ami Graham,Jennifer A. DiNieri,Scott J. Russo,Vaishnav Krishnan,Sumana Chakravarty,Joseph Peevey,Nathan Oehrlein,Shari G. Birnbaum,Martha Hotz Vitaterna,Paul Orsulak,Joseph S. Takahashi,Eric J. Nestler,William A. Carlezon,Colleen A. McClung +15 more
TL;DR: It is shown that mice carrying a mutation in the Clock gene display an overall behavioral profile that is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, and an increase in the reward value for cocaine, sucrose, and medial forebrain bundle stimulation.
Journal ArticleDOI
Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
William A. Carlezon,Cécile Béguin,Jennifer A. DiNieri,Michael H. Baumann,Michele R. Richards,Mark S. Todtenkopf,Richard B. Rothman,Zhongze Ma,David Y.W. Lee,Bruce M. Cohen +9 more
TL;DR: SalvA data provide additional support for the hypothesis that stimulation of brain κ-opioid receptors triggers depressive-like signs in rats and raise the possibility that decreases in extracellular concentrations of DA within the NAc contribute to these effects.
Journal ArticleDOI
Altered Sensitivity to Rewarding and Aversive Drugs in Mice with Inducible Disruption of cAMP Response Element-Binding Protein Function within the Nucleus Accumbens
Jennifer A. DiNieri,Christina L. Nemeth,Aram Parsegian,Tiffany L. Carle,Vsevolod V. Gurevich,Eugenia V. Gurevich,Rachael L. Neve,Eric J. Nestler,William A. Carlezon +8 more
TL;DR: The possibility that disruption of CREB in the NAc influences motivation by simultaneously facilitating reward and reducing depressive-like states such as anhedonia and dysphoria is raised.
Journal ArticleDOI
N-Methylacetamide Analog of Salvinorin A: A Highly Potent and Selective κ-Opioid Receptor Agonist with Oral Efficacy
Cécile Béguin,David N. Potter,Jennifer A. DiNieri,Thomas A. Munro,Michele R. Richards,Tracie A. Paine,Loren Berry,Zhiyang Zhao,Bryan L. Roth,Wei Xu,Lee-Yuan Liu-Chen,William A. Carlezon,Bruce M. Cohen +12 more
TL;DR: Although salvA and NMA are similar in potency and selectivity as KOR agonists in vitro, NMA has improved stability and longer lasting actions that might make it more useful for studies of Kor agonist effects in animals and humans.