Jennifer B. Hall

TL;DR: Recent research on nanoparticle physicochemical properties important for protein binding, techniques for isolation and identification of nanoparticle-bound proteins, and how these proteins can influence particle biodistribution and biocompatibility are reviewed.

TL;DR: The ideal nanoparticle platform is the one whose integrity is not disturbed in the complex biological environment, which provides extended circulation in the blood to maximize delivery to the target site, is not toxic to blood cellular components, and is "invisible" to the immune cells which can remove it from circulation.

TL;DR: Effect of protein binding on the nanoparticle hydrodynamic size, elements of coagulation, and the complement system have been investigated and the difference in size measurements obtained from dynamic light scattering, electron microscopy, and scanning probe microscopy are discussed.

TL;DR: In this paper, the authors describe validation of an in vitro assay for the analysis of nanoparticle hemolytic properties and discuss observed nanointerferences with the assay, and propose alternative methods to avoid misleading results from nanoparticles.

TL;DR: Progress is highlighted for a few methods that are uniquely useful for nanoparticles or are indicative of their toxicity or efficacy.