Showing papers in "Nanomedicine: Nanotechnology, Biology and Medicine in 2009"

TL;DR: The extracellular biosynthesis of Ag-NPs is reported using a common fungus, Alternaria alternata, and the antifungal activity of fluconazole was enhanced in presence of silver nanoparticles against the test fungi.

TL;DR: Effect of protein binding on the nanoparticle hydrodynamic size, elements of coagulation, and the complement system have been investigated and the difference in size measurements obtained from dynamic light scattering, electron microscopy, and scanning probe microscopy are discussed.

TL;DR: The most sensitive antimicrobial activity has been observed against methamphetamine-resistant S. aureus followed by methicillin-resistant Staphylococcus epidermidis and Streptococcus pyogenes, whereas only moderate antimacterial activity was seen against Salmonella typhi and Klebsiella pneumoniae.

TL;DR: It is hypothesized that the efficacy of doxorubicin (DOX) can be maximized and dose-limiting cardiotoxicity minimized by controlled release from PEGylated nanoparticles.

TL;DR: In this paper, gold nanoparticles (AuNPs) have been used for the enhancement of radiation effects on bovine aortic endothelial cells of superficial x-ray radiation therapy and megavoltage electron radiation therapy beams.

TL;DR: The AMG finding of a significant reduction in the stained area of the liver sections and number of macrophages loaded with gold nanoparticles reveals that over time an increasing part of the total amount ofgold nanoparticles in the liver is contained in fewer macrophage accumulated in growing clusters.

TL;DR: It is shown that CeO(2) nanoparticles are well tolerated by live animals, and they prevent the onset of radiation-induced pneumonitis when delivered to live animals exposed to high doses of radiation.

TL;DR: The comparative study conducted on methotrexate (MTX)-bearing SLNs revealed that the formulation based on Compritol 888 ATO could noticeably improve the oral bioavailability of MTX, presumably following SLNs constituting lipid digestion and co-absorption through lymphatic transport and route.

TL;DR: The results show that nanoparticles can be effectively targeted into extravascular tumor tissue and that targeting can enhance the activity of a therapeutic nanoparticle.

TL;DR: In this article, a review of vector-based siRNA delivery is presented, focusing on different pathways for SiRNA delivery and summarizes recent progress made in the use of vector based siRNA technology.

TL;DR: In this article, the growth-inhibitory effect of metal oxide nanoparticles (NPs) over a wide concentration range (10-1000 μg/mL) on an environmentally relevant gram-negative model microorganism, Escherichia coli, was studied.

TL;DR: This review focuses on microemulsions, polymeric nanoparticles, liposomes, solid lipid nanop articles, and drug nanocrystals as novel high efficiency delivery systems of anti-inflammatory drugs in ophthalmic applications.

TL;DR: This review is concerned with emerging targeted nanomedicines and multifunctional carriers capable of combining targeted drug delivery and imaging in the field of pharmaceutical applications and the significant toxicity issues associated with these nanomediines are explored.

TL;DR: The presence of apatite-coated TiO2 shows antibacterial activity in the presence of black light or visible light is suggested, suggesting its potential use in reducing the risk of microorganism transmission for textile applications.

TL;DR: The potential use of nanodiamonds and their derivatives for single particle imaging in cells, drug delivery, protein separation and biosensing, as well as an overview of the recent progress in this exciting field are presented.

TL;DR: Nanodiamond (ND) holds several momentous properties such as good biocompatibility, excellent photostability and facile surface functionalizability, which make it a highly promising nanomaterial for both in vitro and in vivo applications.

TL;DR: It is suggested that CYT-6091 delivers TNF-alpha preferentially to the tumor and that upon T NF-alpha degradation, the liver takes up Au, which is cleared slowly over time.

TL;DR: Analysis of the time-dependent intracellular spatial distribution of the NPs demonstrated that they reside in lysosomes (final degrading organelles) within 40 minutes of incubation, which can be used to tailor nanoscale devices for effective cell targeting and delivery.

TL;DR: Investigation of the effect of various physicochemical features of multiwalled carbon nanotubes (MWCNTs) on toxicity and biocompatibility with cultured human neuroblastoma cells by using MTT, WST-1, Hoechst, and oxidative stress assays indicates that concentrations of 5-10 mug/mL MWCNTs seem ideal for studies on the design and development of artificial CNT nanovectors for gene and drug therapy against cancer.

TL;DR: By exploiting the unique optical properties of quantum dot, the conjugation of quantum dots with photosensitizers and targeting agents could provide a new class of versatile multifunctional nanoparticles for both diagnostic imaging and therapeutic applications.

TL;DR: In this article, the authors investigated the effect of self-assembling peptide nanofiber scaffold (SAPNS) for the reconstruction of acutely injured brain and found that the graft of SAPNS integrated well with the host tissue with no obvious gaps.

TL;DR: Polymer nanoparticles seemed to be devoid of any irritant effect on cornea, iris, and conjunctiva for as long as 24 hours after application, thus apparently a suitable inert carrier for ophthalmic drug delivery.

TL;DR: A nanoparticle-based technique of targeted drug delivery through the blood-brain barrier is discussed, showing two orders of magnitude greater efficiency compared to other known NP drug carriers.

TL;DR: The synthesis and potential applications of mixed nanoparticles prepared with generations 4 and 5 (G4, G5) poly(amidoamine) (PAMAM) dendrimers and plasmid DNA proved to be effective for gene delivery to colon and liver cancer cells in vitro, as well as in vivo.

TL;DR: The analysis of the plasmonic nanobubbles suggests them as theranostic probes, which can be tuned and optically guided at cell level from diagnosis to delivery and therapy during one fast process.

TL;DR: The current state and future perspectives of nanomedicine are briefly explored, as well as recommendations to accelerate the translation of nano-enabled technologies from laboratory discovery into clinical practice.

TL;DR: The reported method is feasible for achieving prolonged drug release through self-assembly of polyelectrolyte multilayers on natural drug crystals and hydrophilicity of ART crystals was improved after encapsulation.

TL;DR: This article focuses on how nanotechnology can serve to improve the delivery of antiretroviral medicines, termed nanoART, across the blood-brain barrier and affect the biodistribution and clinical benefit for HIV-1 disease.

TL;DR: The prolonged effect of ris peridone was obtained from the risperidone formulations administered subcutaneously, and this may improve the treatment of psychotic disorders by dose reduction and to reduce the dose-dependent extrapyramidal side effects.

TL;DR: The results support the continued development of macrophage-mediated nanoART carriage for HIV-1 disease and show dose-dependent reduction in progeny virion production and HIV- 1 p24 antigen.