J
Jennifer L. Martin
Researcher at University of Wollongong
Publications - 218
Citations - 11411
Jennifer L. Martin is an academic researcher from University of Wollongong. The author has contributed to research in topics: DsbA & Protein structure. The author has an hindex of 54, co-authored 212 publications receiving 10668 citations. Previous affiliations of Jennifer L. Martin include University of Queensland & Griffith University.
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Thioredoxin —a fold for all reasons
TL;DR: The thioredoxin fold is a characteristic protein structural motif that has been found in five distinct classes of proteins that have the common property of interacting with cysteine-containing substrates.
REVIEW Human Sulfotransferases and Their Role in Chemical Metabolism
Niranjali Gamage,Amanda C. Barnett,Nadine Hempel,Ronald G. Duggleby,Kelly F. Windmill,Jennifer L. Martin,Michael E. McManus +6 more
TL;DR: SULTs have a wide tissue distribution and act as a major detoxification enzyme system in adult and the developing human fetus as mentioned in this paper, and they are also capable of bioactivating procarcinogens to reactive electrophiles.
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SAM (dependent) I AM: the S-adenosylmethionine-dependent methyltransferase fold.
TL;DR: The S-adenosylmethionine-dependent methyltransferase enzymes share little sequence identity, but incorporate a highly conserved structural fold, and residues that bind the common cofactor are poorly conserved.
Journal ArticleDOI
Human sulfotransferases and their role in chemical metabolism
Niranjali Gamage,Amanda C. Barnett,Nadine Hempel,Ronald G. Duggleby,Kelly Windmill,Jennifer L. Martin,Michael E. McManus +6 more
TL;DR: Interindividual variation in sulfonation capacity may be important in determining an individual's response to xenobiotics, and recent studies have begun to suggest roles for SULT polymorphism in disease susceptibility.
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Functional-Group Contributions to Drug Receptor Interactions
TL;DR: The binding constants and structural components of 200 drugs and enzyme inhibitors have been used to calculate the average binding energies of 10 common functional groups, and as expected, charged groups bind more strongly than polar groups, which in turn bind more tightly than nonpolar groups.