J
Jennifer L. Mitchell
Researcher at Brigham and Women's Hospital
Publications - 3
Citations - 386
Jennifer L. Mitchell is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Signal transduction & Histone code. The author has an hindex of 2, co-authored 2 publications receiving 363 citations.
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Journal ArticleDOI
Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes
Michael J. Malecki,Cheryll Sanchez-Irizarry,Jennifer L. Mitchell,Gavin Histen,Mina L. Xu,Jon C. Aster,Stephen C. Blacklow +6 more
TL;DR: Together, these studies show that leukemia-associated HD domain mutations render NOTCH1 sensitive to ligand-independent proteolytic activation through two distinct mechanisms.
Journal ArticleDOI
Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2
Wendy R. Gordon,Didem Vardar-Ulu,Sarah L'Heureux,Todd Ashworth,Michael J. Malecki,Cheryll Sanchez-Irizarry,Debbie G. McArthur,Gavin Histen,Jennifer L. Mitchell,Jon C. Aster,Stephen C. Blacklow +10 more
TL;DR: S1 cleavage has distinct effects on the surface expression of notch1 and Notch2, but is not generally required for physiologic or pathophysiologic activation of Notch proteins.
Posted ContentDOI
Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation
Rebecca J. Harris,Maninder Heer,Mark Levasseur,Tyrell N. Cartwright,Bethany Weston,Jennifer L. Mitchell,Jonathan Coxhead,Luke Gaughan,Lisa Prendergast,Daniel Rico,Jonathan M.G. Higgins +10 more
TL;DR: In this paper , the authors analyzed the genome-wide distribution of Histone H3 at threonine-3 (H3T3ph) and H3K4me3 during mitosis.