S
Stephen C. Blacklow
Researcher at Harvard University
Publications - 191
Citations - 20910
Stephen C. Blacklow is an academic researcher from Harvard University. The author has contributed to research in topics: Notch signaling pathway & Receptor. The author has an hindex of 67, co-authored 178 publications receiving 18861 citations. Previous affiliations of Stephen C. Blacklow include Massachusetts Institute of Technology & Stanford University.
Papers
More filters
Journal ArticleDOI
Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia
Andrew P. Weng,Andrew P. Weng,Adolfo A. Ferrando,Adolfo A. Ferrando,Woojoong Lee,Woojoong Lee,John P. Morris,John P. Morris,Lewis B. Silverman,Lewis B. Silverman,Cheryll Sanchez-Irizarry,Cheryll Sanchez-Irizarry,Stephen C. Blacklow,Stephen C. Blacklow,A. Thomas Look,A. Thomas Look,Jon C. Aster,Jon C. Aster +17 more
TL;DR: These findings greatly expand the role of activated NOTCH1 in the molecular pathogenesis of human T-ALL and provide a strong rationale for targeted therapies that interfere with NOTCH signaling.
Journal ArticleDOI
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
Andrew P. Weng,John M. Millholland,Yumi Yashiro-Ohtani,Marie Laure Arcangeli,Arthur Lau,Carol Wai,Cristina Del Bianco,Carlos G. Rodriguez,Hong Sai,John W. Tobias,Yue-Ming Li,Michael S. Wolfe,Cathy Shachaf,Dean W. Felsher,Stephen C. Blacklow,Warren S. Pear,Jon C. Aster +16 more
TL;DR: In this article, the authors identified c-myc as a direct target of Notch1 in Notch-dependent T-ALL cell lines, in which Notch accounts for the majority of cmyc expression.
Journal ArticleDOI
A trimeric structural domain of the HIV-1 transmembrane glycoprotein.
TL;DR: A stable, proteinase-resistant structure comprising two peptides, N-51 and C-43, derived from a recombinant protein fragment of the gp41 ectodomain is identified, suggesting that this α-helical, trimeric complex is the core of the fusion-competent state of the HIV-1 envelope.
Journal ArticleDOI
Direct inhibition of the NOTCH transcription factor complex
Raymond E. Moellering,Raymond E. Moellering,Melanie G. Cornejo,Tina N. Davis,Cristina Del Bianco,Jon C. Aster,Stephen C. Blacklow,Andrew L. Kung,D. Gary Gilliland,D. Gary Gilliland,Gregory L. Verdine,James E. Bradner,James E. Bradner +12 more
TL;DR: It is demonstrated that direct, high-affinity binding of the hydrocarbon-stapled peptide SAHM1 prevents assembly of the active transcriptional complex at a critical protein–protein interface in the NOTCH transactivation complex.
Journal ArticleDOI
MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors.
Lizi Wu,Jon C. Aster,Stephen C. Blacklow,Robert J. Lake,Spyros Artavanis-Tsakonas,James D. Griffin +5 more
TL;DR: Cl clone MAML1, a human homologue of the Drosophila gene Mastermind, and show that it encodes a protein of 130 kD localizing to nuclear bodies that functions as a transcriptional co-activator for NOTCH signalling.