J
Jennifer Varley
Researcher at University of Leicester
Publications - 71
Citations - 4867
Jennifer Varley is an academic researcher from University of Leicester. The author has contributed to research in topics: Gene & Li–Fraumeni syndrome. The author has an hindex of 34, co-authored 71 publications receiving 4756 citations. Previous affiliations of Jennifer Varley include Leicester Royal Infirmary.
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Journal ArticleDOI
Relative frequency and morphology of cancers in carriers of germline TP53 mutations.
Jillian M. Birch,Robert Alston,Richard J. Q. McNally,D. G. R. Evans,Anna Kelsey,Martin Harris,Osborn B. Eden,Jennifer Varley +7 more
TL;DR: Although breast carcinoma and sarcomas were numerically most frequent, the greatest increases relative to general population rates were in adrenocortical carcinomas and phyllodes tumour.
Journal Article
Alterations to either c-erbB-2(neu) or c-myc proto-oncogenes in breast carcinomas correlate with poor short-term prognosis.
TL;DR: A significant (p less than 0.02) correlation between an altered c-myc gene and a very poor short-term prognosis is found and Alterations to neu also correlated well with poor short term prognosis.
Journal ArticleDOI
Li-Fraumeni syndrome--a molecular and clinical review.
TL;DR: While the definition of classic LFS has become generally accepted, a number of groups have relaxed the description to include incomplete Li-Fraumeni syndrome (a proband with an affected first-degree relative; Brugieres et al, 1993) and Li Fraumeni-like syndrome (LFL).
Journal Article
Germ-Line Mutations of TP53 in Li-Fraumeni Families: An Extended Study of 39 Families
Jennifer Varley,G. Mcgown,M. Thorncroft,Mauro Santibanez-Koref,Anna Kelsey,K. J. Tricker,D G R Evans,JM Birch +7 more
TL;DR: Six of the new mutations described here are the same as those previously identified in other Li-Fraumeni families and are missense mutations at codons 245, 248, and 273 (in two families); a nonsense mutation at codon 209; and a mutation at the splice donor site in exon 4.
Journal ArticleDOI
Are there low-penetrance TP53 Alleles? evidence from childhood adrenocortical tumors.
Jennifer Varley,Gail McGown,Mary R Thorncroft,Louise A James,Geoffrey P. Margison,Gill Forster,D. Gareth Evans,Martin Harris,Anna Kelsey,Jillian M Birch +9 more
TL;DR: Analysis of cases of childhood adrenocortical tumors unselected for family history and germline TP53 mutations in >80%, making this the highest known incidence of a germline mutation in a tumor-suppressor gene in any cancer, provides evidence that certain TP53 alleles confer relatively low penetrance for predisposition to the development of cancer.