J
Jenny Allen
Researcher at South African Medical Research Council
Publications - 4
Citations - 3141
Jenny Allen is an academic researcher from South African Medical Research Council. The author has contributed to research in topics: Tuberculosis & Sputum. The author has an hindex of 3, co-authored 4 publications receiving 2951 citations.
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Journal ArticleDOI
Rapid molecular detection of tuberculosis and rifampin resistance.
Catharina Boehme,Pamela Nabeta,Doris Hillemann,Mark P. Nicol,Shubhada Shenai,Fiorella Krapp,Jenny Allen,Rasim Tahirli,Robert Blakemore,Roxana Rustomjee,Ana Milovic,Martin Jones,Sean M. O'Brien,David H. Persing,Sabine Ruesch-Gerdes,Eduardo Gotuzzo,Camilla Rodrigues,David Alland,Mark D. Perkins +18 more
TL;DR: The MTB/RIF test provided sensitive detection of tuberculosis and rifampin resistance directly from untreated sputum in less than 2 hours with minimal hands-on time.
Journal ArticleDOI
The diarylquinoline TMC207 for multidrug-resistant tuberculosis
Andreas H. Diacon,Alexander S. Pym,Martin P. Grobusch,R. F. Patientia,Roxana Rustomjee,Liesl Page-Shipp,Christoffel Pistorius,Rene Krause,Mampedi Bogoshi,Gavin J. Churchyard,Amour Venter,Jenny Allen,Juan Carlos Palomino,Tine De Marez,Rolf van Heeswijk,Nacer Lounis,Paul Meyvisch,Johan Verbeeck,Wim Parys,Karel de Beule,Koen Andries,David F Mc Neeley +21 more
TL;DR: The clinical activity of TMC207 validates ATP synthase as a viable target for the treatment of tuberculosis.
Journal Article
A Phase II study of the sterilising activities of ofloxacin, gatifloxacin and moxifloxacin in pulmonary tuberculosis.
Roxana Rustomjee,Christian Lienhardt,Thomas P. Kanyok,Geraint Davies,J Levin,Thuli Mthiyane,C. Reddy,A. W Sturm,F. A. Sirgel,Jenny Allen,David Coleman,B Fourie,Denis A. Mitchison,Gatifloxacin for Tb (Oflotub) study team +13 more
TL;DR: GFX and MFX improve the sterilising activity of regimens and might shorten treatment; their progression into Phase III trials therefore seems warranted.
Journal ArticleDOI
Urine lipoarabinomannan (LAM) and antimicrobial usage in seriously-ill HIV-infected patients with sputum smear-negative pulmonary tuberculosis
Thuli Mthiyane,Jonny Peter,Jenny Allen,Cathy Connolly,Malika Davids,Roxana Rustomjee,Roxana Rustomjee,Timothy H. Holtz,Lesibana Anthony Malinga,Keertan Dheda +9 more
TL;DR: Urine LAM testing in sputum smear-negative severely-ill hospitalized patients with TB-HIV co-infection and advanced immunosuppression, offered an immediate rule-in diagnosis in one-third of empirically treated patients, suggesting LAM, by providing a rapid alternative diagnosis, could potentially reduce antibiotic overusage in such patients thereby reducing health-care costs and facilitating antibiotic stewardship.