G
Gavin J. Churchyard
Researcher at University of the Witwatersrand
Publications - 315
Citations - 17193
Gavin J. Churchyard is an academic researcher from University of the Witwatersrand. The author has contributed to research in topics: Tuberculosis & Population. The author has an hindex of 69, co-authored 290 publications receiving 15154 citations. Previous affiliations of Gavin J. Churchyard include University of London & Brigham and Women's Hospital.
Papers
More filters
Journal ArticleDOI
The diarylquinoline TMC207 for multidrug-resistant tuberculosis
Andreas H. Diacon,Alexander S. Pym,Martin P. Grobusch,R. F. Patientia,Roxana Rustomjee,Liesl Page-Shipp,Christoffel Pistorius,Rene Krause,Mampedi Bogoshi,Gavin J. Churchyard,Amour Venter,Jenny Allen,Juan Carlos Palomino,Tine De Marez,Rolf van Heeswijk,Nacer Lounis,Paul Meyvisch,Johan Verbeeck,Wim Parys,Karel de Beule,Koen Andries,David F Mc Neeley +21 more
TL;DR: The clinical activity of TMC207 validates ATP synthase as a viable target for the treatment of tuberculosis.
Journal ArticleDOI
The geographic diversity of nontuberculous mycobacteria isolated from pulmonary samples: an NTM-NET collaborative study
Wouter Hoefsloot,Jakko van Ingen,Claire Andrejak,Kristian Ängeby,Rosine Bauriaud,Pascale Bémer,Natalie Beylis,Martin J. Boeree,Juana Cacho,Violet N. Chihota,Erica Chimara,Gavin J. Churchyard,Raquel Cias,Rosa Daza,Charles L. Daley,P. N. Richard Dekhuijzen,Diego Domingo,Francis Drobniewski,Jaime Esteban,Maryse Fauville-Dufaux,Dorte Bek Folkvardsen,Noel Gibbons,Enrique Gómez-Mampaso,Rosa Gonzalez,Harald Hoffmann,Po-Ren Hsueh,Alexander Indra,Tomasz Jagielski,Frances Jamieson,Mateja Janković,Eefje Jong,Joseph Keane,Wo Jung Koh,Berit Lange,Sylvia Cardoso Leão,Rita Macedo,Turid Mannsåker,Theodore K. Marras,Jeannette Maugein,Heather Milburn,Tamas Mlinkó,Nora Morcillo,Kozo Morimoto,Dimitrios Papaventsis,Elia Palenque,Mar Paez-Peña,Claudio Piersimoni,Monika Polanova,Nalin Rastogi,Elvira Richter,Maria Jesus Ruiz-Serrano,Anabela Santos Silva,M. Pedro Da Silva,M. Pedro Da Silva,Hülya Şimşek,Dick van Soolingen,Nora Szabó,Rachel Thomson,Teresa Fernandez,Enrico Tortoli,Sarah E. Totten,Greg Tyrrell,Tuula Vasankari,Miguel Villar,Renata Walkiewicz,Kevin L. Winthrop,Dirk Wagner +66 more
TL;DR: A snapshot of NTM species distribution demonstrates that the species distribution among NTM isolates from pulmonary specimens in the year 2008 differed by continent and differed by country within these continents.
Journal ArticleDOI
HIV infection and tuberculosis in South Africa: an urgent need to escalate the public health response.
Salim S. Abdool Karim,Salim S. Abdool Karim,Gavin J. Churchyard,Quarraisha Abdool Karim,Quarraisha Abdool Karim,Stephen D. Lawn +5 more
TL;DR: By use of the framework of the Strategic Plans for South Africa for tuberculosis and HIV/AIDS, this work provides prioritised four-step approaches for tuberculosis control, HIV prevention, and HIV treatment.
Journal ArticleDOI
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Keertan Dheda,Tawanda Gumbo,Gary Maartens,Kelly E. Dooley,Ruth McNerney,Megan Murray,Jennifer Furin,Edward A. Nardell,Leslie London,Erica Lessem,Grant Theron,Paul D. van Helden,Stefan Niemann,Matthias Merker,David W. Dowdy,Annelies Van Rie,Annelies Van Rie,Gilman Kit Hang Siu,Jotam G. Pasipanodya,Camilla Rodrigues,Taane G. Clark,F. A. Sirgel,Aliasgar Esmail,Hsien-Ho Lin,Sachin R Atre,H. Simon Schaaf,Kwok Chiu Chang,Christoph Lange,Payam Nahid,Zarir F Udwadia,C. Robert Horsburgh,Gavin J. Churchyard,Gavin J. Churchyard,Dick Menzies,Anneke C. Hesseling,Eric L. Nuermberger,Helen McIlleron,Kevin P. Fennelly,Eric Goemaere,Ernesto Jaramillo,Marcus Low,Carolina Morán Jara,Nesri Padayatchi,Robin M. Warren +43 more
TL;DR: Several lines of evidence suggest that alternative mechanisms-including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial to the pathogenesis of drug-resistant tuberculosis.
Journal ArticleDOI
Tuberculosis in sub-Saharan Africa: opportunities, challenges, and change in the era of antiretroviral treatment.
Elizabeth L. Corbett,Elizabeth L. Corbett,Barbara J. Marston,Gavin J. Churchyard,Kevin M. De Cock,Kevin M. De Cock +5 more
TL;DR: Tuberculosis epidemiology in Africa and policy implications of HIV/AIDS treatment scale-up are reviewed, showing that failure to successfully integrate HIV and tuberculosis control will threaten the viability of both programmes.