J
Jenny L. Wiley
Researcher at Research Triangle Park
Publications - 134
Citations - 6230
Jenny L. Wiley is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Cannabinoid & Cannabinoid receptor. The author has an hindex of 41, co-authored 131 publications receiving 5584 citations. Previous affiliations of Jenny L. Wiley include Virginia Commonwealth University & VCU Medical Center.
Papers
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Journal ArticleDOI
3-(1′,1′-Dimethylbutyl)-1-deoxy-Δ8-THC and related compounds: synthesis of selective ligands for the CB2 receptor
John W. Huffman,John Liddle,Shu Yu,Mie Mie Aung,Mary E. Abood,Jenny L. Wiley,Billy R. Martin +6 more
TL;DR: The synthesis and pharmacology of 15 1-deoxy-delta8-THC analogues, several of which have high affinity for the CB2 receptor are described, and the affinities of each compound for theCB1 and CB2 receptors were determined employing previously described procedures.
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Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.
John W. Huffman,Gulay Zengin,Ming-Jung Wu,Jianzhong Lu,George Hynd,Kristen Bushell,Alicia L. S. Thompson,Simon M. Bushell,Cindy Tartal,Dow P. Hurst,Patricia H. Reggio,Dana E. Selley,Michael P. Cassidy,Jenny L. Wiley,Billy R. Martin +14 more
TL;DR: Three new highly selective CB(2) receptor agonists were identified and docking studies indicated that the CB(1) receptor affinities of these compounds were consistent with their aromatic stacking interactions in the aromatic microdomain of theCB( 1) receptor.
Journal Article
Structure-activity relationships of indole- and pyrrole-derived cannabinoids.
Jenny L. Wiley,David R. Compton,Dong Dai,Julia A.H. Lainton,Michelle Phillips,John W. Huffman,Billy R. Martin +6 more
TL;DR: A series of indole- and pyrrole-derived cannabinoids was developed, in which the morpholinoethyl group was replaced with another cyclic structure or with a carbon chain that more directly corresponded to the side chain of Delta9-THC and were tested for CB1 binding affinity and in a battery of in vivo tests.
Journal ArticleDOI
Sex differences in cannabinoid pharmacology: A reflection of differences in the endocannabinoid system?
TL;DR: A greater understanding of the mechanisms underlying sexually dimorphic effects of cannabinoids will facilitate development of sex-specific approaches to treat marijuana dependence and to use cannabinoid-based medications therapeutically.
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Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)
Julie A. Marusich,Kateland R. Antonazzo,Jenny L. Wiley,Bruce E. Blough,John S. Partilla,Michael H. Baumann +5 more
TL;DR: Findings represent the first evidence that second generation analogs of MDPV are catecholamine-selective uptake blockers which may pose risk for addiction and adverse effects in human users.