J
Jenny Xie
Researcher at University of Massachusetts Medical School
Publications - 8
Citations - 508
Jenny Xie is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: DNA repair & Fanconi anemia. The author has an hindex of 8, co-authored 8 publications receiving 466 citations. Previous affiliations of Jenny Xie include Harvard University.
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Journal ArticleDOI
The FANCJ/MutLα interaction is required for correction of the cross-link response in FA-J cells
TL;DR: The functional role of the FancJ/MutLα complex demonstrates a novel link between FA and MMR, and predicts a broader role for FANCJ in DNA damage signaling independent of BRCA1.
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HSP90 Shapes the Consequences of Human Genetic Variation
Georgios I. Karras,Song Yi,Nidhi Sahni,Máté Fischer,Jenny Xie,Marc Vidal,Alan D. D'Andrea,Luke Whitesell,Susan Lindquist +8 more
TL;DR: A compensatory FANCA somatic mutation from an "experiment of nature" in monozygotic twins both prevented anemia and reduced HSP90 binding and provides one plausible mechanism for the variable expressivity and environmental sensitivity of genetic diseases.
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Targeting the FANCJ–BRCA1 interaction promotes a switch from recombination to polη-dependent bypass
TL;DR: It is found that in human cells BRCA1 binding to FANCJ is critical to regulate DNA repair choice and promote genomic stability, and unregulated FancJ function could be associated with cancer and/or chemoresistance.
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Crosstalk between BRCA‐Fanconi anemia and mismatch repair pathways prevents MSH2‐dependent aberrant DNA damage responses
TL;DR: ICL sensitivity of cells lacking the interaction between FANCJ and the MMR protein MLH1 is suppressed by depletion of the upstream mismatch recognition factor MSH2, suggesting that regulation of MSH 2‐dependent DNA damage response underlies the importance of interactions between BRCA‐FA and MMR pathways.
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FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response
Jenny Xie,Min Peng,Shawna Guillemette,Steven Quan,Stephanie Maniatis,Yuliang Wu,Aditya Venkatesh,Scott A. Shaffer,Robert M. Brosh,Sharon B. Cantor +9 more
TL;DR: It is proposed that the dynamic regulation of FANCJ acetylation is critical for robust DNA damage response, recombination-based processing, and ultimately checkpoint maintenance.