J
Jens Knudsen
Researcher at University of Southern Denmark
Publications - 176
Citations - 9633
Jens Knudsen is an academic researcher from University of Southern Denmark. The author has contributed to research in topics: Acyl-CoA-binding protein & Fatty acid. The author has an hindex of 52, co-authored 176 publications receiving 9193 citations. Previous affiliations of Jens Knudsen include Copenhagen University Hospital & Odense University.
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Journal ArticleDOI
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling.
Nils J. Færgeman,Jens Knudsen +1 more
TL;DR: The observations that the ryanodine-senstitive Ca2+-release channel is regulated by long-chain acyl-CoA esters in the presence of a molar excess of acyl -CoA binding protein and that acetyl- coA carboxylase, the AMP kinase kinase and the Escherichia coli transcription factor FadR are affected by low nanomolar concentrations of Acyl- CoA indicate that long- chain acyl
Journal ArticleDOI
Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology
Thomas Kirkegaard,Anke G. Roth,Nikolaj H.T. Petersen,Ajay K. Mahalka,Ole Dines Olsen,Irina Moilanen,Alicja Zylicz,Jens Knudsen,Konrad Sandhoff,Christoph Arenz,Paavo K.J. Kinnunen,Jesper Nylandsted,Marja Jäättelä +12 more
TL;DR: In this article, heat shock protein 70 (Hsp70) is shown to stabilize lysosomes by binding to an endolysosomal anionic phospholipid bis(monoacylglycero)phosphate (BMP), an essential co-factor for acid sphingomyelin metabolism.
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal
Thomas Kirkegaard,Anke G. Roth,Nikolaj H.T. Petersen,Ajay K. Mahalka,Ole Dines Olsen,Irina Moilanen,Alicja Zylicz,Jens Knudsen,Konrad Sandhoff,Christoph Arenz,Paavo K.J. Kinnunen,Jesper Nylandsted,Marja Jäättelä +12 more
TL;DR: It is shown that Hsp70 stabilizes lysosomes by binding to an endolysosomal anionic phospholipid bis(monoacylglycero)phosphate (BMP), an essential co-factor for lysOSomal sphingomyelin metabolism.
Journal ArticleDOI
Probing the Nature of Noncovalent Interactions by Mass Spectrometry. A Study of Protein−CoA Ligand Binding and Assembly
Carol V. Robinson,Evonne W. Chung,Birthe B. Kragelund,Jens Knudsen,Robin T. Aplin,F.M. Poulsen,Christopher M. Dobson +6 more
TL;DR: Despite the very low dissociation constants of the acyl CoA ligand complexes high ratios of ligand-to-protein concentration in the electrospray solution were found to increase the proportion of intact complex observed in the spectrum.
Journal ArticleDOI
Acyl-CoA-binding protein (ACBP) can mediate intermembrane acyl-CoA transport and donate acyl-CoA for beta-oxidation and glycerolipid synthesis
TL;DR: In this paper, the dissociation constants for octanoyl-CoA, dodecanoylscoA and hexadecanoyl CoA binding to ACBP were determined by using titration microcalorimetry.