J
Jens M. Bruun
Researcher at Aarhus University
Publications - 112
Citations - 6643
Jens M. Bruun is an academic researcher from Aarhus University. The author has contributed to research in topics: Adipose tissue & Medicine. The author has an hindex of 36, co-authored 95 publications receiving 6066 citations. Previous affiliations of Jens M. Bruun include University of Copenhagen & Steno Diabetes Center.
Papers
More filters
Journal ArticleDOI
Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans.
Jens M. Bruun,Aina S. Lihn,Camilla Verdich,Steen B. Pedersen,Søren Toubro,Arne Astrup,Bjørn Richelsen +6 more
TL;DR: The inverse relationship between plasma adip onectin and cytokines in vivo and the cytokine-induced reduction in adiponectin mRNA in vitro suggests that endogenous cytokines may inhibit adiponECTin.
Journal ArticleDOI
Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT.
TL;DR: MCP-1 is correlated with specific macrophage markers, adiposity, and AT localization, but the relationship seems to be related to the number of AT-resident macrophages, which suggests that these antidiabetic compounds have antiinflammatory properties improving the low-grade inflammatory state observed in obesity.
Journal ArticleDOI
Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects
TL;DR: Markers of inflammation were particularly reduced in AT, whereas SM does not contribute to this attenuation of whole body inflammation, and hypocaloric diet and increased physical activity improved insulin sensitivity and reduced low-grade inflammation.
Journal ArticleDOI
Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects.
TL;DR: The findings demonstrate that MCP-1 is produced in isolated human adipocytes and support the hypothesis that weight loss is beneficial by improving the low-grade inflammation observed in obesity.
Journal ArticleDOI
Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects.
TL;DR: Investigation of adiponectin mRNA levels in both visceral and subcutaneous abdominal adipose tissue from lean and obese subjects found sub cutaneous AT to be more important for circulating adiponECTin levels than visceral AT.