J
Jérémie Fournier Dit Chabert
Researcher at University of Salford
Publications - 3
Citations - 405
Jérémie Fournier Dit Chabert is an academic researcher from University of Salford. The author has contributed to research in topics: Combretastatin & Tubulin. The author has an hindex of 3, co-authored 3 publications receiving 372 citations.
Papers
More filters
Journal ArticleDOI
Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: Synthesis and biological evaluation of antivascular activity
Sylvie Ducki,David Rennison,Meiko Woo,Alexander Kendall,Jérémie Fournier Dit Chabert,Alan T McGown,Nicholas J. Lawrence,Nicholas J. Lawrence +7 more
TL;DR: The alpha-methyl chalcone SD400 is a potent inhibitor of tubulin assembly and possesses potent anticancer activity and remarkable cell shape changes were elicit in HUVEC cells, consistent with vasculature damaging activity.
Journal ArticleDOI
1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin
Kristin Odlo,Jean Hentzen,Jérémie Fournier Dit Chabert,Sylvie Ducki,Osman A. B. S. M. Gani,Ingebrigt Sylte,Martina Skrede,Vivi Ann Flørenes,Trond Vidar Hansen +8 more
TL;DR: Molecular modeling experiments involving 12f and the colchicine binding site of alpha,beta-tubulin showed that the triazole moiety interacts with beta- Tubulin via hydrogen bonding with several amino acids.
Journal ArticleDOI
Combretastatin-like chalcones as inhibitors of microtubule polymerisation. Part 2: Structure-based discovery of alpha-aryl chalcones.
Sylvie Ducki,Grant Mackenzie,Ben Greedy,Simon Armitage,Jérémie Fournier Dit Chabert,Elizabeth Bennett,James H. Nettles,James P. Snyder,Nicholas J. Lawrence,Nicholas J. Lawrence +9 more
TL;DR: The proposed models, in agreement with published biochemical data, show that combretastatin A4 binds to the colchicine site of beta-tubulin and that chalcones assume an orientation similar to that of podophyllotoxin.