V
Vivi Ann Flørenes
Researcher at Oslo University Hospital
Publications - 98
Citations - 4999
Vivi Ann Flørenes is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Melanoma & Cancer. The author has an hindex of 41, co-authored 97 publications receiving 4751 citations. Previous affiliations of Vivi Ann Flørenes include Rikshospitalet–Radiumhospitalet & Oslo and Akershus University College of Applied Sciences.
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Journal Article
Levels of nm23 messenger RNA in metastatic malignant melanomas: inverse correlation to disease progression.
Vivi Ann Flørenes,Steinar Aamdal,Ola Myklebost,Gunhild Mari Mælandsmo,Øyvind S. Bruland,Øystein Fodstad +5 more
TL;DR: The association found here between low levels of nm23 mRNA and the malignant potential of melanomas suggests that the nm23 gene may be implicated in the mechanism of disease progression in some types of human cancer.
Journal ArticleDOI
MDM2 Gene Amplification and Transcript Levels in Human Sarcomas: Relationship to TP53 Gene Status
Vivi Ann Flørenes,Gunhild Mari Mælandsmo,Anne Forus,Åshild Andreassen,Ola Myklebost,Øystein Fodstad +5 more
TL;DR: Signs are provided that increased MDM2 expression level, caused by gene amplification or altered regulation of transcription, is involved in tumor progression of some, but not all, sarcoma subtypes.
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1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin
Kristin Odlo,Jean Hentzen,Jérémie Fournier Dit Chabert,Sylvie Ducki,Osman A. B. S. M. Gani,Ingebrigt Sylte,Martina Skrede,Vivi Ann Flørenes,Trond Vidar Hansen +8 more
TL;DR: Molecular modeling experiments involving 12f and the colchicine binding site of alpha,beta-tubulin showed that the triazole moiety interacts with beta- Tubulin via hydrogen bonding with several amino acids.
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Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma.
David J. Easty,Philip J. Mitchell,Ketan Patel,Vivi Ann Flørenes,Richard A. Spritz,Dorothy C. Bennett +5 more
TL;DR: In this article, the expression of 9 protein tyrosine kinases (PTKs) genes in melanocytes was examined in cell lines derived from defined stages of melanoma progression, by Northern blotting and in some cases immunoblotting, and they also tested cells from 2 animal models of particular stages in progression, as well as uncultured biopsies of metastatic melanoma.
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Up-regulation of ephrin-a1 during melanoma progression
David J. Easty,Simon P. Hill,Mei-Yu Hsu,Mary E. Fallowfield,Vivi Ann Flørenes,Meenhard Herlyn,Dorothy C. Bennett +6 more
TL;DR: The findings are consistent with 2 possible roles for ephrin‐A1 in melanoma development: it may promote melanocytic cell growth or survival and induce vascularization in advanced melanomas, both effects may be potentiated by inflammatory responses.