Jeremy J. Watts

TL;DR: The findings suggest that glutamate metabolites are altered in CHR, a site of key functional and structural abnormalities in schizophrenia, and associations between hippocampal glutamate metabolites and glial activation are explored.

TL;DR: The first review of the effects of exogenous cannabinoids on the endocannabinoid system in humans with and without psychotic disorders is conducted, finding the most well established finding is the down-regulation of cannabinoid CB1 receptors after chronic and recent cannabis exposure.

TL;DR: The results of this study suggest that TSPO levels in cannabis users, particularly in those with cannabis use disorder, are higher than those in non-cannabis-using controls.

TL;DR: Elevated nigral DA responsiveness to stress is observed in antipsychotic-naïve SCZ, and this study explores how DA release in the SN and striatum might be related.

TL;DR: This review will highlight groundbreaking studies in the CRISPR-Cas9 functional genetics field and discuss strengths and limitations of this technology for neurological disease applications and provide practical guidance on navigating the many choices that need to be made when implementing a CRISpr- Cas9 functional genetic screen for the study of neurological diseases.