Jeroen DeGroot

TL;DR: First experimental evidence that protein turnover is a major determinant in AGE accumulation in different collagen types is provided, thereby providing the first reasonable estimates of the half-lives of these collagens.

TL;DR: Increasing cartilage AGE crosslinking by in vitro incubation with threose resulted in increased stiffness of the collagen network, which may contribute to the age-related failure ofThe collagen network in human articular cartilage to resist damage.

TL;DR: The level of evidence of the association between overweight and developing hand osteoarthritis is moderate according to best-evidence synthesis, and further high-quality cohort or case–control studies are needed to elucidate the role of weight in hand osteOarthritis.

TL;DR: Increased pyridinoline cross-link levels were found in the matrix deposited by SSc fibroblasts, demonstrating a clear link between mRNA levels of the putative TLH gene (PLOD2) and the hydroxylation of lysine residues within the telopeptides.

TL;DR: Tendon degeneration is shown to be an active, cell-mediated process that may result from a failure to regulate specific MMP activities in response to repeated injury or mechanical strain, and the short head of biceps brachii tendons shows little protein turnover, whereas control supraspinatus tendons show relatively high turnover mediated by the activity of MMP-1.