J
Johan M. TeKoppele
Researcher at Utrecht University
Publications - 68
Citations - 7752
Johan M. TeKoppele is an academic researcher from Utrecht University. The author has contributed to research in topics: Cartilage & Collagen network. The author has an hindex of 47, co-authored 68 publications receiving 7329 citations.
Papers
More filters
Journal ArticleDOI
Effect of collagen turnover on the accumulation of advanced glycation end products.
Nicole Verzijl,Jeroen DeGroot,Suzanne R. Thorpe,Ruud A. Bank,J. Nikki Shaw,Timothy J. Lyons,Johannes W. J. Bijlsma,Floris P J G Lafeber,John W. Baynes,Johan M. TeKoppele +9 more
TL;DR: First experimental evidence that protein turnover is a major determinant in AGE accumulation in different collagen types is provided, thereby providing the first reasonable estimates of the half-lives of these collagens.
Journal ArticleDOI
Crosslinking by advanced glycation end products increases the stiffness of the collagen network in human articular cartilage: A possible mechanism through which age is a risk factor for osteoarthritis
Nicole Verzijl,Jeroen DeGroot,Chaya Ben Zaken,Orit Braun-Benjamin,Alice Maroudas,Ruud A. Bank,Joe Mizrahi,Casper G. Schalkwijk,Suzanne R. Thorpe,John W. Baynes,Johannes W. J. Bijlsma,Floris P J G Lafeber,Johan M. TeKoppele +12 more
TL;DR: Increasing cartilage AGE crosslinking by in vitro incubation with threose resulted in increased stiffness of the collagen network, which may contribute to the age-related failure ofThe collagen network in human articular cartilage to resist damage.
Journal ArticleDOI
Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis
Annemarie J. van der Slot,Anne-Marie Zuurmond,Alfons F.J. Bardoel,Cisca Wijmenga,Hans E.H. Pruijs,David Sillence,Jürgen Brinckmann,David Abraham,Carol M. Black,Nicole Verzijl,Jeroen DeGroot,Roeland Hanemaaijer,Johan M. TeKoppele,Tom W J Huizinga,Ruud A. Bank +14 more
TL;DR: Increased pyridinoline cross-link levels were found in the matrix deposited by SSc fibroblasts, demonstrating a clear link between mRNA levels of the putative TLH gene (PLOD2) and the hydroxylation of lysine residues within the telopeptides.
Journal ArticleDOI
Ageing and zonal variation in post-translational modification of collagen in normal human articular cartilage. The age-related increase in non-enzymatic glycation affects biomechanical properties of cartilage.
TL;DR: Investigation of the accumulation of non-enzymatic glycation products in healthy human articular cartilage, its relation to tissue remodelling and its role in tissue stiffening found that maturation of cartilage in the second decade of life starts in the upper half of the tissue, and occurs last in the tissue close to the bone.
Journal ArticleDOI
The role of collagen in determining bone mechanical properties
TL;DR: The results of this study indicate that the toughness and strength of bone decreases significantly with increasing collagen denaturation, whereas the elastic modulus of bone is almost constant irrespective of collagenDenaturation.