J
Jeroen van den Brakel
Researcher at Genmab
Publications - 9
Citations - 1490
Jeroen van den Brakel is an academic researcher from Genmab. The author has contributed to research in topics: Antibody & Monoclonal antibody. The author has an hindex of 7, co-authored 8 publications receiving 1409 citations.
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Journal ArticleDOI
Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
Jessica L. Teeling,Ruth R. French,Mark S. Cragg,Jeroen van den Brakel,Marielle Pluyter,Haichun Huang,Claude H.T. Chan,Paul W. H. I. Parren,C. Erik Hack,Michael Dechant,Thomas Valerius,Jan G. J. van de Winkel,Martin J. Glennie +12 more
TL;DR: With increasing evidence that mAb therapeutic activity in vivo depends on complement activation, these new CD20 reagents with their slow off-rates and increased potency in CDC hold considerable promise for improved clinical activity.
Journal ArticleDOI
The Biological Activity of Human CD20 Monoclonal Antibodies Is Linked to Unique Epitopes on CD20
Jessica L. Teeling,Wendy J.M. Mackus,Luus Wiegman,Jeroen van den Brakel,Stephen A. Beers,Ruth R. French,Tom van Meerten,Saskia B. Ebeling,Tom Vink,Jerry W. Slootstra,Paul W. H. I. Parren,Martin J. Glennie,Jan G.J. van den Winkel,Jan G.J. van den Winkel +13 more
TL;DR: It is concluded that recognition of the novel epitope cooperates with slow off-rate in determining the activity of CD20 Ab in activation of complement and induction of tumor cell lysis.
Journal ArticleDOI
Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody
Wim K. Bleeker,Martin E. Munk,Wendy J.M. Mackus,Jeroen van den Brakel,Marielle Pluyter,Martin J. Glennie,Jan G. J. van de Winkel,Jan G. J. van de Winkel,Paul W. H. I. Parren +8 more
TL;DR: It is concluded that, once saturation of CD20 throughout the body has been reached by high initial dosing, plasma concentrations that maintain target saturation on circulating cells (5–10 μg/ml) are probably sufficient for sustained biological activity.
Journal ArticleDOI
Epidermal Growth Factor Receptor (EGFR) Antibody-Induced Antibody-Dependent Cellular Cytotoxicity Plays a Prominent Role in Inhibiting Tumorigenesis, Even of Tumor Cells Insensitive to EGFR Signaling Inhibition
Marije B. Overdijk,Sandra Verploegen,Jeroen van den Brakel,Jeroen J. Lammerts van Bueren,Tom Vink,Jan G. J. van de Winkel,Jan G. J. van de Winkel,Paul W. H. I. Parren,Wim K. Bleeker +8 more
TL;DR: ADCC induction by EGFR-specific mAbs represents an important mechanism of action in preventing tumor outgrowth or metastasis in vivo, even of cancers insensitive to EGFR signaling inhibition.
Journal ArticleDOI
A redundant role of the CD3 gamma-immunoreceptor tyrosine-based activation motif in mature T cell function.
Mariëlle C. Haks,Tanina A. Cordaro,Jeroen van den Brakel,John B. A. G. Haanen,Evert de Vries,Jannie Borst,Paul Krimpenfort,Ada M. Kruisbeek +7 more
TL;DR: The role of the CD3γ chain and theCD3γ-ITAM in peripheral T cell activation and differentiation to effector function is reported on.