Jerome Amir Singh

TL;DR: While healthcare professionals in SA have become resilient and adept at making difficult decisions in the face of resource limitations, a surge in COVID-19 cases could place a severe strain on the country's critical care services and necessitate unprecedented rationing decisions.

TL;DR: Five recommendations are formulated to help achieve a balance between early access to research findings and its negative consequences, and high level consultations should be convened to formulate clear principles and policies for the publication and dissemination of non-peer reviewed research results.

TL;DR: In July 2012 the US Food and Drug Administration endorsed its Antiviral Products Advisory Committee’s recommendation and changed the indication of tenofovir disoproxil fumarate/emtricitabine (TDF/ FTC or Truvada) to include pre-exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 in adults.

TL;DR: Since SARS-CoV2 was declared a Public Health Emergency of International Concern , those tasked with the stewardship of public health at a global, regional, and local level—policymakers, politicians, scientists, drug regulators, health officials, professional associations, journal editors, publishers, and clinicians—have displayed rushed decisions and lapses in judgment in their handling of chloroquine and hydroxychloroquine as potential COVID-19 therapeutics and prophylactics.

TL;DR: International guidance documents on informed consent and engagement are reviewed and applied to the genetically modified mosquito research context and proponents of gene drive field research should look to the Eliminate Dengue field trials, cluster randomised trials, and pragmatic clinical trials for guidance regarding how the solicitation of individual informed consent of host communities ought to be managed.