J
Jerry D. Clark
Researcher at Pfizer
Publications - 18
Citations - 411
Jerry D. Clark is an academic researcher from Pfizer. The author has contributed to research in topics: Diethyl ether & Claisen rearrangement. The author has an hindex of 8, co-authored 18 publications receiving 383 citations. Previous affiliations of Jerry D. Clark include Indiana University & Pharmacia.
Papers
More filters
Journal ArticleDOI
[1,3]-Sigmatropic rearrangement of allyl vinyl ethers at ambient temperature in 3.0 M lithium, perchlorate-diethyl ether
Journal ArticleDOI
Water as a solvent for the Claisen rearrangement: practical implications for synthetic organic chemistry
TL;DR: The influence accelerante de l'eau comme solvant, sur la vitesse de la transposition de Claisen a ete demontree pour divers substrats as discussed by the authors.
Journal ArticleDOI
2-(Diethylamino)ethanethiol, a New Reagent for the Odorless Deprotection of Aromatic Methyl Ethers
TL;DR: A new reagent for the deprotection of aromatic methyl ethers, 2-(diethylamino)ethanethiol, is reported, which affords the corresponding phenols in good to excellent yields on a wide variety of substrates.
Journal ArticleDOI
Pilot Plant Preparation of an αvβ3 Integrin Antagonist. Part 1. Process Research and Development of a (S)-β-Amino Acid Ester Intermediate: Synthesis via a Scalable, Diastereoselective Imino-Reformatsky Reaction
Jerry D. Clark,Gerald A. Weisenburger,D. Keith Anderson,Pierre-Jean Colson,Edney Albert D,Donald J. Gallagher,H. Peter Kleine,Carl M. Knable,Melissa K. Lantz,Christine M. V. Moore,James Murphy,Thomas Rogers,Peter G. Ruminski,Ajit S. Shah,Neil Storer,Bruce E. Wise +15 more
TL;DR: In this article, four process research investigations are directed toward discerning a scalable, enantioselective method for preparing (S)-β-amino acid ester 3, a key intermediate to the αvβ3 integrin antagonist 1.
Journal ArticleDOI
Retro aza Diels-Alder reactions of 2-azanorbornenes: improved methods for the unmasking of primary amines
Paul A. Grieco,Jerry D. Clark +1 more
TL;DR: The unmasking of primary amines via the heterocycloreversion of N-alkyl-2-azanorbornenes can be catalyzed by either copper(II) or a sulfonic acid based ion exchange resin which obviates the necessity of employing a reactive dienophile to trap the cyclopentadiene as it is produced as mentioned in this paper.