J
Jessica E. Wagenseil
Researcher at Washington University in St. Louis
Publications - 76
Citations - 3871
Jessica E. Wagenseil is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Elastin & Elastic fiber. The author has an hindex of 25, co-authored 65 publications receiving 3269 citations. Previous affiliations of Jessica E. Wagenseil include University of Washington & Children's National Medical Center.
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Vascular Extracellular Matrix and Arterial Mechanics
TL;DR: By correlating vessel mechanics with physiological blood pressure across animal species and in mice with altered vessel compliance, it is shown that cardiac and vascular development are physiologically coupled, and there is evidence for a universal elastic modulus that controls the parameters of ECM deposition in vessel wall development.
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New insights into elastic fiber assembly
TL;DR: A model of elastic fiber assembly is proposed based on the current data that incorporates interactions between elastin, LOXs, fibulins and the microfibril, as well as the pivotal role played by cells in structuring the final functional fiber.
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Elastin in large artery stiffness and hypertension
TL;DR: This review discusses how alterations in the amount, assembly, organization, or chemical properties of the elastic fibers affect arterial stiffness and blood pressure and Therapies that have a direct effect on arterIAL stiffness through alterations to the elastic fiber in the wall may be an effective treatment for essential hypertension.
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Mechanical Properties of Dilated Human Ascending Aorta
Ruth J. Okamoto,Jessica E. Wagenseil,William R. DeLong,Sara J. Peterson,Nicholas T. Kouchoukos,Thoralf M. Sundt +5 more
TL;DR: Changes in mechanical properties suggest that age may influence the risk of aortic dissection or rupture of dilated ascending aorta, associated with Marfan Syndrome, biaxial elastic, or advanced age.
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Effects of elastin haploinsufficiency on the mechanical behavior of mouse arteries.
Jessica E. Wagenseil,Nandan L. Nerurkar,Russell H. Knutsen,Ruth J. Okamoto,Dean Y. Li,Robert P. Mecham +5 more
TL;DR: The mechanical behavior of ELN(+/-) arteries is likely due to the reduced elastin content combined with adaptive remodeling during vascular development, and is similar between genotypes for most arteries.